- Nuclear Wiskott-Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells.
Nuclear Wiskott-Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells.
Genome medicine (2017-10-29)
Nikolai V Kuznetsov, Bader Almuzzaini, Joanna S Kritikou, Marisa A P Baptista, Mariana M S Oliveira, Marton Keszei, Scott B Snapper, Piergiorgio Percipalle, Lisa S Westerberg
PMID29078804
ABSTRACT
The Wiskott-Aldrich syndrome protein (WASp) family of actin-nucleating factors are present in the cytoplasm and in the nucleus. The role of nuclear WASp for T cell development remains incompletely defined. We performed WASp chromatin immunoprecipitation and deep sequencing (ChIP-seq) in thymocytes and spleen CD4 WASp was enriched at genic and intergenic regions and associated with the transcription start sites of protein-coding genes. Thymocytes and spleen CD4 These data place nuclear WASp in proximity with TCF1 and TCF12, essential factors for T cell development.
MATERIALS