Downregulation of UBE2E2 in rat liver cells after hepatocarcinogen treatment facilitates cell proliferation and slowing down of DNA damage response in GST-P-expressing preneoplastic lesions.

Downregulation of UBE2E2 in rat liver cells after hepatocarcinogen treatment facilitates cell proliferation and slowing down of DNA damage response in GST-P-expressing preneoplastic lesions.

Toxicology and applied pharmacology (2017-09-14)

Sayaka Mizukami, Yousuke Watanabe, Yukie Saegusa, Kota Nakajima, Yuko Ito, Yasunori Masubuchi, Toshinori Yoshida, Makoto Shibutani

ABSTRACT

We previously found downregulation of ubiquitin-conjugating enzyme E2E 2 (UBE2E2) in GST-P-positive

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

N-Butyl-N-(4-hydroxybutyl)nitrosamine, ISOPAC^®, ≥90% (GC)

Sigma-Aldrich

β-Naphthoflavone, ≥98%