Home Protein ExpressionPlatelet Derived Growth Factors (PDGF)

Platelet Derived Growth Factors (PDGF)

Jennifer Fries

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.¹ PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. PDGF is mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. PDGF appears to interact with Transforming Growth Factor-1 in accelerating wound healing.² However, PDGF may also be pathogenic in arteriosclerosis and neoplasia.³ The mitogenic activities of all PDGF products are tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.⁴

Materials

Loading

References

1.

Ross R, Glomset J, Kariya B, Harker L. 1974. A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro. Proceedings of the National Academy of Sciences. 71(4):1207-1210. https://doi.org/10.1073/pnas.71.4.1207

2.

Pierce GF, Mustoe TA, Lingelbach J, Masakowski VR, Griffin GL, Senior RM, Deuel TF. 1989. Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms.. 109(1):429-440. https://doi.org/10.1083/jcb.109.1.429

3.

Ross R. 1981. George Lyman Duff Memorial Lecture. Atherosclerosis: a problem of the biology of arterial wall cells and their interactions with blood components.. Arteriosclerosis. 1(5):293-311. https://doi.org/10.1161/01.atv.1.5.293

4.

Raines EW, Ross R. 1985. [58] Purification of human platelet-derived growth factor.749-773. https://doi.org/10.1016/0076-6879(85)09128-5