GRM8
glutamate receptor, metabotropic 8
别名:
GLUR8, GPRC1H, MGLUR8, mGlu8
物种:
Human GRM8 (2918), Mouse Grm8 (14823), Rat Grm8 (60590), domestic guinea pig Grm8 (100725321), naked mole-rat Grm8 (101697666), chicken GRM8 (427853), Domestic Rabbit GRM8 (100328635), dog GRM8 (482270), Horse GRM8 (100071655), cow GRM8 (538360)
UniProtKB ID:
基因ID:
- Human(2918) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
- Mouse(14823) glutamate receptor, metabotropic 8
- Rat(60590) glutamate receptor, metabotropic 8
- domestic guinea pig(100725321) glutamate receptor, metabotropic 8
- naked mole-rat(101697666) glutamate receptor, metabotropic 8
- chicken(427853) glutamate receptor, metabotropic 8
- Domestic Rabbit(100328635) glutamate receptor, metabotropic 8
- dog(482270) glutamate receptor, metabotropic 8
- Horse(100071655) glutamate receptor, metabotropic 8
- cow(538360) glutamate receptor, metabotropic 8
- sheep(101108742) glutamate receptor, metabotropic 8
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