101 kDa

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Epitope: Cytoplasmic Domain

This antibody is generated from guinea pigs immunized with a KLH-conjugated linear peptide selected from residues corresponding to the cytoplasmic domain of rat mGluR8.

Anti-mGluR8 Antibody detects level of mGluR8 & has been published & validated for use in IH.

Evaluated by Western Blot in rat brain lysate. Although intended for use in IHC analysis, a band was observed at ~101kDa.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

This antibody recognizes mGluR8.

Unpurified

Unpurified guinea pig polyclonal serum with 0.05% sodium azide.

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Control
Rat brain lysate

Immunohistochemistry Analysis: : 1:100-500 dilution from a previous lot detected mGluR8 on rat brain tissue.

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