Merck
CN
所有图片(2)

文件

252999

Sigma-Aldrich

尼亚酰铵

95%

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别名:
N-异烟酰-N′-[β-(N-苄基甲酰氨基)乙基]肼, N-苄基-β-(异烟肼)丙酰胺, 吡啶-4-甲酰 2-[2-(苄基氨基甲酰)乙基]酰肼
经验公式（希尔记法）:
C16H18N4O2
CAS号:
51-12-7
分子量:
298.34
Beilstein:
492941
EC 号:
200-079-3
MDL编号:
MFCD00010106
PubChem化学物质编号:
24855254

检测方案

95%

mp

152-154 °C (lit.)

溶解性

methanol: soluble 10 mg/mL, clear, colorless to faintly yellow

SMILES string

O=C(CCNNC(=O)c1ccncc1)NCc2ccccc2

InChI

1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)

InChI key

NOIIUHRQUVNIDD-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128) , MAOB(4129)

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相关类别

一般描述

Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated.

生化/生理作用

非选择性 MAO-A/B 抑制剂。

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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C F Meehan et al.
The Journal of physiology, 590(2), 289-300 (2011-11-23)
Recently, transgenic mice have been created with mutations affecting the components of the mammalian spinal central pattern generator (CPG) for locomotion; however, it has currently only been possible to evoke fictive locomotion in mice, using neonatal in vitro preparations. Here, we demonstrate
Subsensitivity of the beta-adrenergic receptor-linked adenylate cyclase system of rat pineal gland following repeated treatment with desmethylimipramine and nialamide.
J A Moyer et al.
Molecular pharmacology, 19(2), 187-193 (1981-03-01)
F Datiche et al.
Brain research, 671(1), 27-37 (1995-02-06)
Retrograde axonal transport of the cholera toxin B subunit (CTb) was combined with 5-HT immunohistochemistry to determine the origin of the serotonergic innervation of the piriform cortex (PC) in the rat. After iontophoretic CTb injections in the PC, a substantial
E D Schomburg et al.
The Journal of physiology, 536(Pt 2), 605-613 (2001-10-16)
1. Nociceptive reflex pathways to foot extensors were investigated with particular attention given to those not following a flexor reflex (FRA) or withdrawal pattern. 2. In anaemically decapitated, high spinal paralysed cats nociceptive afferents of the foot pad were activated
H Kuribara
Pharmacology, biochemistry, and behavior, 56(1), 9-14 (1997-01-01)
The ambulation-increasing effect of methamphetamine (MAP: 2 mg/kg s.c.) in mice persisted for about 3 h. Tetrabenazine (TBZ: 4 mg/kg s.c.), a depleter of monoamines from the cytoplasmic pool did not increase ambulation on its own. Pretreatment with TBZ at
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