Merck
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文件

764019

Sigma-Aldrich

二苯基环辛炔-PEG4-氢化琥珀酰亚胺酯

≥90%

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别名:
DBCO-PEG4-NHS酯, DBCO-PEG4-SE, DBCO-PEG4-氢化琥珀酰亚胺酯
经验公式（希尔记法）:
C34H39N3O10
分子量:
649.69
MDL编号:
MFCD26793797
PubChem化学物质编号:
329767092
NACRES:
NA.22

质量水平

100

检测方案

≥90%

形式

paste

reaction suitability

reaction type: click chemistry
reagent type: linker

官能团

NHS ester

储存温度

−20°C

SMILES string

O=C(CCC(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

InChI

1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38)

InChI key

RRCXYKNJTKJNTD-UHFFFAOYSA-N

相关类别

应用

琥珀酰亚胺酯（NHS，胺反应活性）官能化环辛烷衍生物，用来将环辛烷部分插入含有化合物或生物分子的氨基找那个。环辛烷可以用于种促进免铜电极化学环加成反应。这一聚乙二醇会和叠氮官能化化合物或生物分子反应，而不需要Cu（I）催化，就能形成稳定的三唑连接。

应用包括：
  • 蛋白质-多肽偶联物
  • 抗体-酶或抗体药物偶联物
  • 蛋白质或多肽-寡核苷酸偶联物
  • 表面修饰
聚乙二醇-PEG4-N-氢化琥珀酰亚胺酯可以通过少铜点击反应，用来合成前列腺特异性膜抗体（PSMA）目标单光子发射计算体层摄影（SPECT）试剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Huang-Chiao Huang et al.
Small (Weinheim an der Bergstrasse, Germany), e1800236-e1800236 (2018-07-03)
The past three decades have witnessed notable advances in establishing photosensitizer-antibody photo-immunoconjugates for photo-immunotherapy and imaging of tumors. Photo-immunotherapy minimizes damage to surrounding healthy tissue when using a cancer-selective photo-immunoconjugate, but requires a threshold intracellular photosensitizer concentration to be effective.
Clinton H Hansen et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(39), 10367-10372 (2017-09-13)
Protein detection and quantification play critical roles in both basic research and clinical practice. Current detection platforms range from the widely used ELISA to more sophisticated, and more expensive, approaches such as digital ELISA. Despite advances, there remains a need
PSMA?targeted SPECT agents: Mode of binding effect on in vitro performance.
Nedrow?Byers JR, et al.
Prostate, 73(4), 355-362 (2013)
Matthias Krumb et al.
Cells, 9(9) (2020-09-17)
Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic
Hong Pan et al.
Biomaterials, 181, 199-209 (2018-08-08)
Enterovirus 71 (EV71), the major pathogen of hand-foot-and-mouth disease (HFDM), can cause severe neurological and respiratory manifestations in young children. Viral spread route and tissue tropism are key factors contributing to different pathogenicity of EV71, however it remains a challenge
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