CF0022
Phenylsulfanyltetrafluoroethyl trimethylsilane
表单
liquid
反应适用性
reaction type: C-C Bond Formation
应用
After being activated with silicophilic activators, like fluorides, alkoxides or carboxylates, phenylsulfanyltetrafluoroethyl trimethylsilane acts as nucleophilic phenylsulfanyltetrafluoroethylation reagent towards electrophiles such as aromatic aldehydes. A phenylsulfanyltetrafluoroethyl moiety incorporated in the substrate can be treated with tributyltin hydride and generate the corresponding fluoroalkyl radical. If the substrate lacks any olefins, it can be reduced to tetrafluoroethyl group whereas if the substrate contains an olefin in the correct spatial orientation, it can lead to an intramolecular cyclization affording tetrafluorinated cyclic structures.
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法律信息
Product of CF Plus Chemicals.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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目前的氟烷基化工具包括Togni试剂、高价碘全氟烷基化试剂、氟烷基溴化物、硅烷类和羧酸盐类以及用于后期氟烷基化的磺酰氟类。
Fluoroalkylation toolbox expands with various reagents for late-stage fluoroalkylation in organic synthesis and medicinal chemistry.
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