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Merck
CN

D-073

5α-二氢睾酮(DHT)标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

别名:

5 α-二氢睾丸激素 溶液, 5-α-二氢睾丸激素, DHT, 二氢睾酮, 5α−DHT 溶液

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关于此项目

经验公式（希尔记法）:
C19H30O2
化学文摘社编号:
521-18-6
分子量:
290.44
NACRES:
NA.24
PubChem Substance ID:
329798632
UNSPSC Code:
41116107
MDL number:
MFCD00003667

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InChI

1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1

SMILES string

C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI key

NVKAWKQGWWIWPM-ABEVXSGRSA-N

grade

certified reference material

Quality Level

300

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

format

single component solution

storage temp.

−70°C

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General description

该认证加标溶液®适用于从临床和诊断测试和内分泌学到运动测试的各种 GC/MS 和 LC/MS 应用。

5α-二氢睾酮（DHT）是一种类固醇激素，是天然雄激素睾酮的代谢物，通过 NADPH 依赖性酶 5α-还原酶的作用形成。它涉及广泛的疾病，例如男性秃发、良性前列腺增生、以及前列腺癌等。作为合成代谢类固醇，DHT也被用作性能增强药物，以促进肌肉生长。

Application

该认证标准物质（CRM）还可作如下用途：
  • 使用台式气相色谱-质谱联用法（GC-MS）同时分析人血清样品中的睾酮和 5α-二氢睾酮
  • 通过液相色谱-电喷雾电离-串联质谱法（LC/ESI-MS/MS）测定睾酮和 5α-二氢睾酮在吡啶酸及其类似物的质子亲和衍生反应中的含量
  • 通过气相色谱-串联质谱法（GC-MS/MS）测定黑头鲦鱼血浆和睾丸样品中的睾酮和 5α-二氢睾酮
  • 根据世界反兴奋剂机构（WADA）的要求，采用高分辨率全扫描-电喷雾-液相色谱（HR-FS-ESI-LC）结合四极轨道阱质谱（Q/Orbitrap MS）对尿样中表睾酮、睾酮、5α-二氢睾酮、去氢表雄酮、雄酮和乙胆甾醇酮进行多残留筛选。
  • 通过稳定同位素稀释液相色谱-电喷雾电离-串联质谱法（SID-LC-ESI-MS/MS）对使用吡啶甲酸进行衍生化后的 9 种羟基雄激素及其偶联物进行定量分析

Features and Benefits

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试，以确保准确性和保质期
  • 使用合格的精密天平进行重量准备，以确保最小不确定性
  • 氩气环境下火焰密封，装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式，以提高实验室效率

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

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Paulo A Saldanha et al.
Clinical and experimental pharmacology & physiology, 40(3), 181-189 (2013-01-03)
The aim of the present study was to determine the effects of androgens in the regulation of human umbilical artery (HUA) contractility. The short-term effects of testosterone on the tone of the HUA were investigated, as were the long-term effects
Paula M Marchetti et al.
Annals of clinical biochemistry, 50(Pt 2), 95-107 (2013-02-23)
Dihydrotestosterone (DHT) is the most potent natural androgen in humans. There has been an increasing interest in this androgen and its role in the development of primary and secondary sexual characteristics as well as its potential roles in diseases ranging
Angel On Kei Chan et al.
Clinical chemistry, 59(5), 798-806 (2013-03-21)
5α-Reductase 2 deficiency (5ARD) is a known cause of 46,XY disorders of sex development (DSD). Traditionally, the diagnosis relies on dihydrotestosterone (DHT) measurement, but the results are often equivocal, potentially leading to misdiagnosis. We reviewed alternative approaches for diagnosis of
Julia Johansson et al.
PloS one, 8(1), e54357-e54357 (2013-01-26)
In rats with dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS), repeated low-frequency electrical stimulation of acupuncture needles restores whole-body insulin sensitivity measured by euglycemic hyperinsulinemic clamp. We hypothesized that electrical stimulation causing muscle contractions and manual stimulation causing needle sensation have
Juan Wen et al.
The Prostate, 73(10), 1069-1081 (2013-02-21)
Androgen modulation of angiogenesis in prostate cancer may be not directly mediated by androgen receptor (AR) as AR is not detected in the prostatic endothelial cells. We examined the paracrine stimulation of cell proliferation by prostate tumor cells and its
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