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Merck
CN

T-073

L-甲状腺素（T4） 溶液

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

别名:

L-甲状腺素, 3,3′,5,5″-四碘代-L-甲状腺原氨酸, 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸, T4

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线性分子式:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
化学文摘社编号:
51-48-9
分子量:
776.87
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329826617
MDL number:
MFCD00002595
Beilstein/REAXYS Number:
2228515

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产品名称

L-甲状腺素（T4） 溶液, 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol with 0.1N NH3

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

223 °C (dec.) (lit.)

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

Quality Level

300

Gene Information

human ... THRA(7067), THRB(7068)

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相关类别

Biochem/physiol Actions

L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。

General description

甲状腺素或T4是一种甲状腺激素，负责调节身体′的基础代谢率，对生长、发育以及心脏和神经系统功能至关重要。通过LC-MS/MS测量游离和总T4血清水平，以确定甲状腺功能亢进或甲状腺功能减退以及监测合成甲状腺激素的治疗。该认证加标溶液® 适合用作制备线性标准品、校准品和对照品的起始物料，适用于LC-MS/MS法。

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

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Aleid G van Wassenaer et al.
Clinical endocrinology, 56(5), 621-627 (2002-05-29)
Thyroid hormone is crucial for brain development during foetal and neonatal life. In very preterm infants, transient low levels of plasma T4 and T3 are commonly found, a phenomenon referred to as transient hypothyroxinaemia of prematurity. We investigated whether breast
R L Sutherland et al.
The Journal of endocrinology, 65(3), 319-332 (1975-06-01)
A competitive binding technique is described for the estimation of the thyroxine (T4)-binding properties of serum proteins in dilute blood serum and lymph. When used in conjunction with an assay for total T4 the following parameters can be estimated: the
Shannon E Scratch et al.
Pediatrics, 133(4), e955-e963 (2014-04-02)
Preterm infants commonly have transient hypothyroxinemia of prematurity after birth, which has been associated with deficits in general intellectual functioning, memory, attention, and academic achievement. However, research has predominantly focused on thyroxine levels in the first 2 weeks of life
Steffen Mayerl et al.
The Journal of clinical investigation, 124(5), 1987-1999 (2014-04-03)
Allan-Herndon-Dudley syndrome (AHDS), a severe form of psychomotor retardation with abnormal thyroid hormone (TH) parameters, is linked to mutations in the TH-specific monocarboxylate transporter MCT8. In mice, deletion of Mct8 (Mct8 KO) faithfully replicates AHDS-associated endocrine abnormalities; however, unlike patients
B Velkeniers et al.
Human reproduction update, 19(3), 251-258 (2013-01-19)
BACKGROUND Previous meta-analyses of observational data indicate that pregnant women with subclinical hypothyroidism have an increased risk of adverse pregnancy outcome. Potential benefits of levothyroxine (LT4) supplementation remain unclear, and no systematic review or meta-analysis of trial findings is available
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商品

Simultaneous Determination of Free T3 and Free T4 in Serum

Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.

实验方案

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

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