Merck
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安全信息

T-073

Supelco

L-甲状腺素（T4） 溶液

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

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别名:
L-甲状腺素, 3,3′,5,5″-四碘代-L-甲状腺原氨酸, 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸, T4
线性分子式:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
CAS号:
51-48-9
分子量:
776.87
Beilstein:
2228515
MDL编号:
MFCD00002595
PubChem化学物质编号:
329826617
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

100 μg/mL in methanol with 0.1N NH3

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

223 °C (dec.) (lit.)

应用

clinical testing
clinical testing

格式

single component solution

储存温度

−20°C

SMILES字符串

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

基因信息

human ... THRA(7067) , THRB(7068)

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相关类别

一般描述

甲状腺素或T4是一种甲状腺激素，负责调节身体′的基础代谢率，对生长、发育以及心脏和神经系统功能至关重要。通过LC-MS/MS测量游离和总T4血清水平，以确定甲状腺功能亢进或甲状腺功能减退以及监测合成甲状腺激素的治疗。该经认证的加标溶液®适合在LC-MS/MS检测方法中用作制备线性标准品、校准品和质控品的起始物料。

生化/生理作用

L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

危险化学品

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R L Sutherland et al.
The Journal of endocrinology, 65(3), 319-332 (1975-06-01)
A competitive binding technique is described for the estimation of the thyroxine (T4)-binding properties of serum proteins in dilute blood serum and lymph. When used in conjunction with an assay for total T4 the following parameters can be estimated: the
Aleid G van Wassenaer et al.
Clinical endocrinology, 56(5), 621-627 (2002-05-29)
Thyroid hormone is crucial for brain development during foetal and neonatal life. In very preterm infants, transient low levels of plasma T4 and T3 are commonly found, a phenomenon referred to as transient hypothyroxinaemia of prematurity. We investigated whether breast
Sonja Heyerdahl et al.
Thyroid : official journal of the American Thyroid Association, 13(11), 1029-1038 (2003-12-04)
Neonatal screening programs for congenital hypothyroidism (CH) were initiated in the 1970s to ensure early treatment in order to prevent mental retardation. With screening, developmental prognosis is considerably improved, but follow-up studies still report developmental delay compared to controls. To
Ihor Hrytsiuk et al.
Archives of pediatrics & adolescent medicine, 156(5), 485-491 (2002-05-01)
To determine the effect of levothyroxine sodium starting dose on cognitive development, growth, or behavior in children with congenital hypothyroidism identified by neonatal screening. Systematic review of cohort studies. Two analyses were performed: a between-study comparison of mean starting dose
L Ashley Watson et al.
The Journal of clinical investigation, 123(5), 2049-2063 (2013-04-09)
Human ATRX mutations are associated with cognitive deficits, developmental abnormalities, and cancer. We show that the Atrx-null embryonic mouse brain accumulates replicative damage at telomeres and pericentromeric heterochromatin, which is exacerbated by loss of p53 and linked to ATM activation.
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实验方案

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

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