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Merck
CN

1.00241

无水柠檬酸粉末

anhydrous powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 330

别名:

2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid

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关于此项目

线性分子式:
HOC(COOH)(CH2COOH)2
化学文摘社编号:
77-92-9
分子量:
192.12
UNSPSC Code:
12352106
EC Index Number:
201-069-1
E Number:
E330
MDL number:
MFCD00011669
Beilstein/REAXYS Number:
782061

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InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

agency

BP, JP, Ph. Eur., USP

reg. compliance

FCC

vapor pressure

<0.1 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

assay

99.5-100.5% substance (anhydrous) basis (alkalimetric)

form

fine powder

potency

3000 mg/kg LD50, oral (Rat)

expl. lim.

8 %, 65 °F

pH

1.7 (20 °C, 100 g/L in H2O)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

bp

200 °C/1013 hPa (decomposition)

mp

153-159 °C (lit.)

solubility

1330 g/L

density

1.665 g/cm3 at 18 °C

cation traces

Al: ≤0.2 ppm, As: ≤1 ppm, Hg: ≤1 ppm, Pb: ≤0.5 ppm, heavy metals (as Pb): ≤5 ppm

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-30°C

Quality Level

500

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid anhydrous powder Emprove® Essential is citric acid present in its water-free, powder form.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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