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Merck
CN

1.00241

SAFC

无水柠檬酸粉末

anhydrous powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 330

别名:

2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid

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关于此项目

线性分子式:
HOC(COOH)(CH2COOH)2
CAS Number:
77-92-9
分子量:
192.12
Beilstein:
782061
MDL编号:
MFCD00011669
UNSPSC代码:
12352106
E编号:
E330
EC索引号:
201-069-1

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Agency

BP
JP
Ph. Eur.
USP

质量水平

500

管理合规性

FCC

蒸汽压

<0.1 hPa ( 20 °C)

产品线

EMPROVE® ESSENTIAL

方案

99.5-100.5% substance (anhydrous) basis (alkalimetric)

表单

fine powder

效能

3000 mg/kg LD50, oral (Rat)

expl. lim.

8 %, 65 °F

pH值（酸碱度）

1.7 (20 °C, 100 g/L in H2O)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

沸点

200 °C/1013 hPa (decomposition)

mp

153-159 °C (lit.)

溶解性

1330 g/L

密度

1.665 g/cm3 at 18 °C

痕量阳离子

Al: ≤0.2 ppm
As: ≤1 ppm
Hg: ≤1 ppm
Pb: ≤0.5 ppm
heavy metals (as Pb): ≤5 ppm

应用

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

储存温度

2-30°C

SMILES字符串

OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

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一般描述

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid anhydrous powder Emprove® Essential is citric acid present in its water-free, powder form.

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H319,H335

危险分类

Eye Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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