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Merck
CN

1.00681

琥珀酸

crystalline, EMPROVE® ESSENTIAL, ChP, NF, JPE, ACS

别名:

丁二酸

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线性分子式:
HOOCCH2CH2COOH
化学文摘社编号:
110-15-6
分子量:
118.09
EC Index Number:
203-740-4
UNSPSC Code:
12352106
Beilstein/REAXYS Number:
1754069
MDL number:
MFCD00002789

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SMILES string

OC(=O)CCC(O)=O

InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

grade

ACS reagent

agency

ChP, JPE, NF

product line

EMPROVE® ESSENTIAL

assay

99.0-100.5% (HPLC)

form

crystalline, solid

autoignition temp.

470 °C

technique(s)

API processing | cocrystal formation: suitable, API processing | salt formation: suitable

bp

235 °C (lit.), 235 °C/1013 hPa

Quality Level

500

transition temp

flash point 206 °C

solubility

58 g/L

density

1.56 g/cm3 at 20 °C

anion traces

chloride (Cl-): ≤0.001%, phosphate (PO43-): ≤0.001%, sulfate (SO42-): ≤0.003%

cation traces

As: ≤0.0002%, Fe: ≤5 ppm, heavy metals (as Pb): ≤0.0020%, heavy metals (as Pb): ≤5 ppm

application(s)

liquid formulation
pharma/biopharma processes
pharmaceutical
solid formulation

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Succinic acid is a commonly used ingredient in pharmaceutical applications. In such applications it has been used primarily for solid oral dosage forms.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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商品

Improving API Solubility using API Processing

Instead of addressing API solubility during formulation, tackle it early during development. Read about the various methods for API processing.

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