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经验公式(希尔记法):
C6H14O6
化学文摘社编号:
分子量:
182.17
UNSPSC Code:
12352201
E Number:
E420
EC Index Number:
200-061-5
MDL number:
产品名称
Parteck® SI 400 (山梨醇), EMPROVE® ESSENTIAL, Ph. Eur., BP, NF, FCC, JSFA, E 420
SMILES string
OC(C(O)C(O)CO)C(O)CO
InChI
1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2
InChI key
FBPFZTCFMRRESA-UHFFFAOYSA-N
agency
BP
JSFA
NF
Ph. Eur.
reg. compliance
FCC
product line
EMPROVE® ESSENTIAL
form
coarse powder
autoignition temp.
420 °C
quality
E 420
particle size
(see specification)
pH
6-7 (20 °C, 100 g/L in H2O)
mp
98-100 °C
transition temp
flash point >100 °C
solubility
2350 g/L
density
1.49 g/cm3 at 20 °C
application(s)
liquid formulation
pharmaceutical
solid formulation
storage temp.
2-25°C
Quality Level
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Application
Parteck® SI excipient is a directly compressible sorbitol which combines excellent tableting behavior, resulting in very robust and shiny tablets, with a pleasant mouthfeel and taste. The unique and large surface area allows for a fast disintegration and dissolution, even at high tablet hardnesses and supports a good content uniformity of low dose API formulations. Parteck® SI excipient comes in a variety of particle sizes and qualities to meet the needs of a very wide range of applications.
Features and Benefits
- Excellent direct compression properties
- High dilution and adsorption capacity
- Larger and highly structured surface area
- Low hygroscopicity
- Low amount of reducing sugars
General description
With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid dosage forms. The products in our Parteck® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
This article describes the use of excipients to help address API stability issues.
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