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Y0001149

盐酸小檗碱

Name: 盐酸小檗碱
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

小檗碱 CRM 氯化物形式, 黄连素

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₈ClNO₄

化学文摘社编号:

633-65-8

分子量:

371.81

PubChem Substance ID:

329830786

UNSPSC Code:

41116107

NACRES:

NA.24

MDL number:

MFCD00011939

Colour Index Number:

75160

Beilstein/REAXYS Number:

3836585

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属性

grade

pharmaceutical primary standard

API family

berberine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COC1=C(C=[N+](CCC2=C3C=C4C(OCO4)=C2)C3=C5)C5=CC=C1OC.[Cl-]

InChI

1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

InChI key

VKJGBAJNNALVAV-UHFFFAOYSA-M

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

肥大细胞中肝素的荧光染色

Biochem/physiol Actions

一种抗生素特性较弱的生物碱。MDR外排泵的底物。小檗碱的抗微生物活性可通过MDR抑制剂5'-甲氧基氢化物（5'-MHC）加强。小檗碱可上调肝癌细胞中Pgp的表达。用小檗碱进行治疗可能会减少化学治疗药物的积累。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Effects of berberine on amelioration of hyperglycemia and oxidative stress in high glucose and high fat diet-induced diabetic hamsters in vivo.

Liu C, Wang Z, Song Y, et al.

BioMed Research International, 2015, 313808-313808 (2015)

Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves.

Victor P Bagla et al.

BMC complementary and alternative medicine, 14, 383-383 (2014-10-09)

Different parts of Podocarpus henkelii have been used in many cultures around the world to treat ailments such as cholera, stomach diseases, rheumatism, cancer, canine distemper in dogs and gall sickness in cattle. The aim of this study was to

Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines.

Mousa O Germoush et al.

Journal of cancer research and clinical oncology, 140(7), 1103-1109 (2014-04-20)

The present study was designed to investigate the possible protective effects of berberine against cyclophosphamide (CP)-induced hepatotoxicity in rats. The experimental rats were treated with berberine orally at a dose of 50 mg/kg for 11 consecutive days after the administration

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货号	GTIN
Y0001149	04061833806296