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经验公式（希尔记法）:
C20H18ClNO4
化学文摘社编号:
分子量:
371.81
PubChem Substance ID:
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
Colour Index Number:
75160
Beilstein/REAXYS Number:
3836585
产品名称
盐酸小檗碱, European Pharmacopoeia (EP) Reference Standard
InChI key
VKJGBAJNNALVAV-UHFFFAOYSA-M
SMILES string
COC1=C(C=[N+](CCC2=C3C=C4C(OCO4)=C2)C3=C5)C5=CC=C1OC.[Cl-]
InChI
1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
grade
pharmaceutical primary standard
API family
berberine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Application
肥大细胞中肝素的荧光染色
Biochem/physiol Actions
一种抗生素特性较弱的生物碱。MDR外排泵的底物。小檗碱的抗微生物活性可通过MDR抑制剂5'-甲氧基氢化物（5'-MHC）加强。小檗碱可上调肝癌细胞中Pgp的表达。用小檗碱进行治疗可能会减少化学治疗药物的积累。
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Victor P Bagla et al.
BMC complementary and alternative medicine, 14, 383-383 (2014-10-09)
Different parts of Podocarpus henkelii have been used in many cultures around the world to treat ailments such as cholera, stomach diseases, rheumatism, cancer, canine distemper in dogs and gall sickness in cattle. The aim of this study was to
Effects of berberine on amelioration of hyperglycemia and oxidative stress in high glucose and high fat diet-induced diabetic hamsters in vivo.
Liu C, Wang Z, Song Y, et al.
BioMed Research International, 2015, 313808-313808 (2015)
Mohamed A Dkhil et al.
Parasitology research, 114(4), 1581-1593 (2015-02-11)
Plant-based natural products are promising sources for identifying novel agents with potential anti-Eimeria activity. This study explores possible effects of berberine on Eimeria papillata infections in the jejunum of male Swiss albino mice. Berberine chloride, when daily administered to mice
Mousa O Germoush et al.
Journal of cancer research and clinical oncology, 140(7), 1103-1109 (2014-04-20)
The present study was designed to investigate the possible protective effects of berberine against cyclophosphamide (CP)-induced hepatotoxicity in rats. The experimental rats were treated with berberine orally at a dose of 50 mg/kg for 11 consecutive days after the administration
Péter Orvos et al.
Fitoterapia, 100, 156-165 (2014-12-08)
Chelidonium majus or greater celandine is spread throughout the world, and it is a very common and frequent component of modern phytotherapy. Although C. majus contains alkaloids with remarkable physiological effect, moreover, safety pharmacology properties of this plant are not
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