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文件

A1270000

精氨酸

Name: 精氨酸
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

L-精氨酸, (S)-2-氨基-5-胍基戊酸

线性分子式:

H₂NC(=NH)NH(CH₂)₃CH(NH₂)CO₂H

CAS号:

74-79-3

分子量:

174.20

Beilstein:

1725413

MDL编号:

MFCD00002635

PubChem化学物质编号:

329770698

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

arginine

制造商/商品名称

EDQM

mp

222 °C (dec.) (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

InChI key

ODKSFYDXXFIFQN-BYPYZUCNSA-N

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一般描述

本品按现行药典规定交付。该产品的所有支持信息，包括SDS和任何产品信息宣传页均由药典发行机构制定并发布。如需更多信息和支持，请见现行药典的网站。

应用

精氨酸EP参考标准品的预期用途是欧洲药典规定的实验室测试。

生化/生理作用

一氧化氮合成酶的底物，可转化为瓜氨酸和一氧化氮 (NO)。通过与一氧化氮相关的机理诱导胰岛素释放。

包装

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

其他说明

可能适用相应的销售限制。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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索取COA

Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis.

Jurgen R Piet et al.

The Journal of infectious diseases, 209(11), 1781-1791 (2013-12-18)

Streptococcus pneumoniae (pneumococcus) is a major human pathogen causing pneumonia, sepsis and bacterial meningitis. Using a clinical phenotype based approach with bacterial whole-genome sequencing we identified pneumococcal arginine biosynthesis genes to be associated with outcome in patients with pneumococcal meningitis.

Perioperative immunonutrition in patients undergoing liver transplantation: a randomized double-blind trial.

Lindsay D Plank et al.

Hepatology (Baltimore, Md.), 61(2), 639-647 (2014-09-13)

Preliminary work suggested that perioperative immunonutrition (IMN) enriched in n-3 fatty acids, arginine, and nucleotides may improve preoperative nutritional status, enhance postoperative recovery, and reduce postoperative infectious complications in patients undergoing liver transplantation (LT). The current study examined these outcomes

LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia.

Phyllis S Y Chong et al.

Cancer research, 74(11), 3043-3053 (2014-04-02)

PRL-3, an oncogenic dual-specificity phosphatase, is overexpressed in 50% of acute myelogenous leukemia (AML) and associated with poor survival. We found that stable expression of PRL-3 confers cytokine independence and growth advantage of AML cells. However, how PRL-3 mediates these

Nitric oxide and L-arginine deficiency in cystic fibrosis.

Hartmut Grasemann et al.

Current pharmaceutical design, 18(5), 726-736 (2012-01-11)

The concentrations of nitric oxide are decreased in airways of patients with cystic fibrosis. The reasons for this nitric oxide deficiency are incompletely understood but may include reduced production from nitric oxide synthases due to decreased expression, the enzymes in

The role of arginine methylation in the DNA damage response.

Yannick Auclair et al.

DNA repair, 12(7), 459-465 (2013-05-21)

Post-translational modifications are well-known modulators of DNA damage signaling and epigenetic gene expression. Protein arginine methylation is a covalent modification that results in the addition of methyl groups to the nitrogen atoms of the arginine side chains and is catalyzed

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精氨酸