产品名称
苯扎隆, European Pharmacopoeia (EP) Reference Standard
SMILES string
[o]1c2c(c(c1CC)C(=O)c3ccc(cc3)O)cccc2
InChI
1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3
InChI key
RFRXIWQYSOIBDI-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
benzarone
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Application
Benzarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
H Köstering et al.
Arzneimittel-Forschung, 35(8), 1303-1306 (1985-01-01)
The analyses on hemostaseological variables are recorded in connection with blood tests in the course of a double-blind study in 41 patients suffering from chronic venous insufficiency of higher degrees of severity. They were treated in addition to compression measures
Effect of anti-inflammatory agents on the glycosaminoglycan metabolism in cultured human synovial cells.
K Kleesiek et al.
Rheumatology international, 2(4), 167-174 (1982-01-01)
Priska Kaufmann et al.
Hepatology (Baltimore, Md.), 41(4), 925-935 (2005-03-31)
Treatment with benzarone or benzbromarone can be associated with hepatic injury. Both drugs share structural similarities with amiodarone, a well-known mitochondrial toxin. Therefore, we investigated the hepatotoxicity of benzarone and benzbromarone as well as the analogues benzofuran and 2-butylbenzofuran. In
H E Knehr et al.
Arzneimittel-Forschung, 33(2), 211-214 (1983-01-01)
The influence of 2-ethyl-3-(4-hydroxy-benzoyl)-benzofurane (benzarone, Fragivic) on the energy metabolism of the wall of the rabbit common carotid artery and the rat portal vein was investigated by measuring the oxygen consumption of in vitro incubated vessel segments. Benzarone increased the
M L Hautekeete et al.
Liver, 15(1), 25-29 (1995-02-01)
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative. Our cases include a 35-year-old woman with (sub)fulminant hepatitis, a 67-year-old woman with macronodular cirrhosis, and a 68-year-old man with severe chronic active hepatitis and cirrhosis, with
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