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B1110000

联苯苄唑

Name: 联苯苄唑
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

1-（对,α-二苯基苄基）咪唑

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关于此项目

经验公式（希尔记法）:

C₂₂H₁₈N₂

化学文摘社编号:

60628-96-8

分子量:

310.39

NACRES:

NA.24

PubChem Substance ID:

329773163

UNSPSC Code:

41116107

MDL number:

MFCD00865567

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属性

grade

pharmaceutical primary standard

API family

bifonazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

c1ccc(cc1)C(c2ccc(cc2)-c3ccccc3)n4ccnc4

InChI

1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H

InChI key

OCAPBUJLXMYKEJ-UHFFFAOYSA-N

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Bifonazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

联苯苄唑是一种咪唑类抗真菌剂，对许多真菌、霉菌、酵母和一些革兰氏阳性菌具有广谱活性。联苯苄唑抑制麦角固醇生物合成蛋白 28 和细胞色素 P450 2B4。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Synthesis, antibacterial and antifungal activities of bifonazole derivatives.

Salomé El Hage et al.

Archiv der Pharmazie, 344(6), 402-410 (2011-03-25)

Two series of chlorinated benzhydryl imidazole and triazole derivatives were synthesized and tested in vitro against representative strains of potent pathogenic bacteria (Staphylococcus aureus CIP 4.83, Escherichia hirae CIP 5855, Pseudomonas aeruginosa CIP 82118, Escherichia coli CIP 53126) and fungi

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

Yonghong Zhao et al.

The Journal of biological chemistry, 281(9), 5973-5981 (2005-12-24)

To better understand ligand-induced structural transitions in cytochrome P450 2B4, protein-ligand interactions were investigated using a bulky inhibitor. Bifonazole, a broad spectrum antifungal agent, inhibits monooxygenase activity and induces a type II binding spectrum in 2B4dH(H226Y), a modified enzyme previously

Interdigital ulcer: an unusual presentation of Candida infection.

Di-Qing Luo et al.

Mycoses, 54(6), e780-e784 (2011-05-28)

Interdigital ulcer is an exceptionally rare condition while erosio interdigitalis blastomycetica is common for candidiasis. Four Chinese patients with Candida interdigital ulcers were reported. The exudates were examined directly and cultured for fungi. Skin biopsies were stained with haematoxylin-eosin and

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货号	GTIN
B1110000	04061833420874