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Merck
CN

BP480

四环素 盐酸盐

British Pharmacopoeia (BP) Reference Standard

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关于此项目

经验公式（希尔记法）:
C22H24N2O8 · HCl
化学文摘社编号:
64-75-5
分子量:
480.90
EC Number:
200-593-8
UNSPSC Code:
41116107
NACRES:
NA.24
Beilstein/REAXYS Number:
3844873
MDL number:
MFCD00078142

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产品名称

四环素 盐酸盐, British Pharmacopoeia (BP) Reference Standard

InChI

1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1

InChI key

XMEVHPAGJVLHIG-FMZCEJRJSA-N

SMILES string

Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

grade

pharmaceutical primary standard

API family

tetracycline

form

crystalline powder

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

220-223 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

−20°C

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相关类别

Biochem/physiol Actions

作用机制：四环素通过细胞膜中的 proin 通道被动扩散，与 30S 核糖体结合，并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合，改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用，这表明起到抗菌作用的是可逆结合的抗生素，而不是不可逆结合的药物。

耐药性机制：这种作用通过细胞壁通透性的丧失而失活。

抗菌谱：包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

Application

Tetracycline hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Lymecycline Capsules
  • Chlortetracycline Eye Ointment
  • Chlortetracycline Veterinary Oral Powder
  • Chlortetracycline Tablets
  • Chlortetracycline Ointment
  • Doxycycline Tablets
  • Doxycycline Prolonged-Release Capsules
  • Doxycycline Dispersible Tablets
  • Doxycycline Capsules
  • Tetracycline Tablets
  • Tetracycline Capsules

    • General description

    This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

    Other Notes

    Sales restrictions may apply.
    Learn how British Pharmacopoeia (BP) sets the standard by offering quality British Pharmacopoeia Chemical Reference Substances (BPCRS).

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    signalword

    Warning

    Hazard Classifications

    Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

    target_organs

    Respiratory system

    存储类别

    11 - Combustible Solids

    wgk

    WGK 2

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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    Adam D Werts et al.
    Cellular and molecular gastroenterology and hepatology, 9(3), 403-423 (2019-11-23)
    Necrotizing enterocolitis (NEC) is a devastating disease of premature infants characterized by Toll-like receptor 4 (TLR4)-dependent intestinal inflammation and enterocyte death. Given that necroptosis is a proinflammatory cell death process that is linked to bacterial signaling, we investigated its potential

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