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Merck
CN

BP576

氢化可的松

British Pharmacopoeia (BP) Assay Standard

别名:

11β,17α,21-三羟基孕酮-4-烯-3,20-二酮, 17-羟基皮质酮标准液, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 皮质醇标准液, 肯德尔氏化合物F, 赖希斯坦氏物质M

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关于此项目

经验公式(希尔记法):
C21H30O5
化学文摘社编号:
分子量:
362.46
NACRES:
NA.24
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
1354819
MDL number:
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grade

pharmaceutical primary standard

API family

hydrocortisone

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

211-214 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... NR3C1(2908)

General description

本产品由现行药典发布和说明。随附的本产品的所有支持信息,包括SDS和任何产品信息彩页,均遵照现行药典许可而编制和发布。
有关更多信息和支持,请参见现行药典网站。

Application

氢化可的松BP参考标准品设计用于英国药典规定的指定质量测试和检测。

也用于专著,例如:
  • 维甲酸、氢化可的松和对苯二酚乳膏
  • 咪康唑和醋酸氢化可的松乳膏
  • 氢化可的松琥珀酸钠注射液
  • 强的松片
  • 咪康唑和氢化可的松乳膏
  • 咪康唑和氢化可的松乳膏
  • 氢化可的松和新霉素乳膏
  • 氢化可的松和克里喹诺软膏
  • 氢化可的松磷酸钠口服液
  • 强的松胃耐药片
  • 氢化可的松磷酸钠
  • 氢化可的松磷酸钠注射液
  • 氢化可的松和克里喹诺乳膏
  • 甲基强的松片
  • 醋酸氢化可的松口服混悬液
  • 氢化可的松乳膏
  • 氢化可的松口腔黏膜片
  • Biochem/physiol Actions

    肾上腺皮质分泌的原始糖皮质激素。
    肾上腺皮质分泌的原始糖皮质激素。它的抗炎效力是皮质酮的三倍,但 Na2+ 保留效力要低得多。

    Other Notes

    可能适用相应的销售限制。


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    pictograms

    Health hazard

    signalword

    Danger

    Hazard Classifications

    Repr. 1A - STOT RE 2

    target_organs

    Adrenal gland,Bone marrow

    存储类别

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    wgk

    WGK 2

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    法规信息

    监管及禁止进口产品

    此项目有



    历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    Florian Hardeveld et al.
    Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
    Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
    Lorenz Goette et al.
    Psychoneuroendocrinology, 54, 115-123 (2015-02-24)
    Social competition is a fundamental mechanism of evolution and plays a central role in structuring individual interactions and communities. Little is known about the factors that affect individuals' competitive success, particularly in humans. Key factors might include stress, a major
    Marianne Oksnes et al.
    The Journal of clinical endocrinology and metabolism, 99(5), 1665-1674 (2014-02-13)
    Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison's disease. The objective of the study was to compare the effects of continuous sc hydrocortisone infusion (CSHI)



    全球贸易项目编号

    货号GTIN
    BP57604061835278206