SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI
1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key
JYGXADMDTFJGBT-VWUMJDOOSA-N
grade
pharmaceutical primary standard
API family
hydrocortisone
form
solid
shelf life
limited shelf life, expiry date on the label
manufacturer/tradename
BP
mp
211-214 °C (lit.)
application(s)
pharmaceutical
pharmaceutical small molecule
format
neat
Gene Information
human ... NR3C1(2908)
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General description
本产品由现行药典发布和说明。随附的本产品的所有支持信息,包括SDS和任何产品信息彩页,均遵照现行药典许可而编制和发布。
有关更多信息和支持,请参见现行药典网站。
有关更多信息和支持,请参见现行药典网站。
Application
氢化可的松BP参考标准品设计用于英国药典规定的指定质量测试和检测。
也用于专著,例如:维甲酸、氢化可的松和对苯二酚乳膏 咪康唑和醋酸氢化可的松乳膏 氢化可的松琥珀酸钠注射液 强的松片 咪康唑和氢化可的松乳膏 咪康唑和氢化可的松乳膏 氢化可的松和新霉素乳膏 氢化可的松和克里喹诺软膏 氢化可的松磷酸钠口服液 强的松胃耐药片 氢化可的松磷酸钠 氢化可的松磷酸钠注射液 氢化可的松和克里喹诺乳膏 甲基强的松片 醋酸氢化可的松口服混悬液 氢化可的松乳膏 氢化可的松口腔黏膜片
也用于专著,例如:
Biochem/physiol Actions
肾上腺皮质分泌的原始糖皮质激素。
肾上腺皮质分泌的原始糖皮质激素。它的抗炎效力是皮质酮的三倍,但 Na2+ 保留效力要低得多。
Other Notes
可能适用相应的销售限制。
signalword
Danger
hcodes
Hazard Classifications
Repr. 1A - STOT RE 2
target_organs
Adrenal gland,Bone marrow
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Florian Hardeveld et al.
Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
Lorenz Goette et al.
Psychoneuroendocrinology, 54, 115-123 (2015-02-24)
Social competition is a fundamental mechanism of evolution and plays a central role in structuring individual interactions and communities. Little is known about the factors that affect individuals' competitive success, particularly in humans. Key factors might include stress, a major
Marianne Oksnes et al.
The Journal of clinical endocrinology and metabolism, 99(5), 1665-1674 (2014-02-13)
Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison's disease. The objective of the study was to compare the effects of continuous sc hydrocortisone infusion (CSHI)
Marieke G N Bos et al.
Psychoneuroendocrinology, 46, 102-113 (2014-06-03)
Retrieval of negative emotional memories is often accompanied by the experience of stress. Upon retrieval, a memory trace can temporarily return into a labile state, where it is vulnerable to change. An unresolved question is whether post-retrieval stress may affect
Karin E Koopman et al.
Hepatology (Baltimore, Md.), 60(2), 545-553 (2014-03-29)
American children consume up to 27% of calories from high-fat and high-sugar snacks. Both sugar and fat consumption have been implicated as a cause of hepatic steatosis and obesity but the effect of meal pattern is largely understudied. We hypothesized
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