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关于此项目
线性分子式:
Pt(NH3)2Cl2
化学文摘社编号:
分子量:
300.05
UNSPSC Code:
41116107
NACRES:
NA.24
EC Number:
239-733-8
MDL number:
grade
pharmaceutical primary standard
API family
cisplatin
form
solid
shelf life
limited shelf life, expiry date on the label
manufacturer/tradename
BP
mp
270 °C (lit.)
application(s)
pharmaceutical
pharmaceutical small molecule
format
neat
storage temp.
2-8°C
SMILES string
N.N.Cl[Pt]Cl
InChI
1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChI key
LXZZYRPGZAFOLE-UHFFFAOYSA-L
General description
本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持，请访问现行药典网站。
Application
顺铂 BP 参考标准品仅用于英国药典中明确规定的实验室检测。
另外用于以下专著：顺铂注射液
另外用于以下专著：
Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
Packaging
单位数量：100mg。可进行调整。本品按药典规定提供。有关当前的单位数量，请访问英国药典
Other Notes
可能适用相应的销售限制。
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signalword
Danger
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
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International urology and nephrology, 52(1), 187-196 (2019-12-13)
Cisplatin could result in a wide range of kidney injuries. During the pathogenetic process, the excessive generation of reactive oxygen species (ROS) induced by cisplatin has been regarded as the initial and critical role, by which DNA damage and cell
Shihong Ma et al.
Journal of cellular biochemistry, 121(5-6), 3256-3265 (2020-01-07)
Aberrant activation of the Hedgehog (Hh)/Gli pathway contributes to the tumorigenesis of several human cancers, including ovarian cancers. We investigated the function of SMO on cell growth, drug resistance, and invasive ability in A2780/DDP cells. Moreover, we also tested the
Teng Wang et al.
Biochimica et biophysica acta. Molecular cell research, 1867(12), 118833-118833 (2020-08-30)
Epithelial-mesenchymal transition (EMT) is considered as the key mechanism involved in cancer metastasis. Several studies showed that various cell membrane calcium channels play different roles in cancer metastasis. In the present study, the potential role of ATPase plasma membrane Ca2+
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| BP809 | 04061835275700 |