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C1050000

鹅去氧胆酸

Name: 鹅去氧胆酸
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

3α，7α-二羟基-5β-胆汁酸, 5β-胆酸-3α，7α-二醇, 鹅去氧胆酸

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关于此项目

经验公式（希尔记法）:

C₂₄H₄₀O₄

化学文摘社编号:

474-25-9

分子量:

392.57

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329774840

MDL number:

MFCD00064142

Beilstein/REAXYS Number:

3219887

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属性

grade

pharmaceutical primary standard

API family

ursodiol

manufacturer/tradename

EDQM

mp

165-167 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1

InChI key

RUDATBOHQWOJDD-BSWAIDMHSA-N

Gene Information

human ... NR1H4(9971)

说明

General description

本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持，请访问现行药典网站。

Application

鹅去氧胆酸EP 参考标准品设计用于欧洲药典规定的实验室测试。

Packaging

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

Other Notes

可能适用相应的销售限制。

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Isolation and characterization of hydrophobic polypeptides in human bile.

M Stark et al.

European journal of biochemistry, 266(1), 209-214 (1999-10-29)

Polypeptides were isolated from human bile by extraction with chloroform/methanol, followed by reversed-phase chromatography in methanol/ethylene chloride and gel filtration in chloroform/methanol. Peptides were characterized by SDS/PAGE, sequence analysis and matrix-assisted laser desorption ionization/time-of-flight mass spectrometry. This identified haemoglobin alpha

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.

Huang Huang et al.

Journal of medicinal chemistry, 55(16), 7037-7053 (2012-08-07)

LBVS of 12480 in-house compounds, followed by HTRF assay, resulted in one nonsteroidal compound (11) with antagonistic activity against FXR (69.01 ± 11.75 μM). On the basis of 11, 26 new derivatives (12a-z) were designed and synthesized accordingly. Five derivatives

Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.

Francesco Saverio Di Leva et al.

Journal of medicinal chemistry, 56(11), 4701-4717 (2013-05-10)

Here, we report suvanine, a marine sponge sesterterpene, as an antagonist of the mammalian bile acid sensor farnesoid-X-receptor (FXR). Using suvanine as a template, we shed light on the molecular bases of FXR antagonism, identifying the essential conformational changes responsible

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全球贸易项目编号

货号	GTIN
C1050000	04061833460559