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Merck
CN

D0480000

去乙酰长春碱

European Pharmacopoeia (EP) Reference Standard

别名:

O4-Deacetylvincaleukoblastine

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关于此项目

经验公式（希尔记法）:
C44H56N4O8
化学文摘社编号:
3352-69-0
分子量:
768.94
MDL number:
MFCD01675267
UNSPSC Code:
41116107
NACRES:
NA.24

主要文件

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SMILES string

[S](=O)(=O)(O)O.N21C[C@H](C[C@@](C2)(O)CC)C[C@@](c8[nH]c9c(c8CC1)cccc9)(c3cc4c(cc3OC)N([C@H]5[C@@]([C@@H]([C@]6([C@@H]7N(CCC754)CC=C6)CC)O)(O)C(=O)OC)C)C(=O)OC

InChI

1S/C44H56N4O8.H2O4S/c1-7-40(52)22-26-23-43(38(50)55-5,34-28(14-18-47(24-26)25-40)27-12-9-10-13-31(27)45-34)30-20-29-32(21-33(30)54-4)46(3)36-42(29)16-19-48-17-11-15-41(8-2,35(42)48)37(49)44(36,53)39(51)56-6;1-5(2,3)4/h9-13,15,20-21,26,35-37,45,49,52-53H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t26-,35+,36-,37-,40+,41-,42?,43+,44+;/m1./s1

InChI key

VSMLZADJIZSDKN-MEFFJABKSA-N

grade

pharmaceutical primary standard

API family

vinblastine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

dry ice

storage temp.

−20°C

相关类别

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Desacetylvinblastine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Muta. 2 - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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M E Spearman et al.
The Journal of pharmacology and experimental therapeutics, 241(2), 695-703 (1987-05-01)
The monoclonal antibody-vinca alkaloid conjugate, KS1/4-DAVLB (LY256787), and free 4-desacetylvinblastine (DAVLB) were administered i.v. to male athymic nude mice bearing P3/UCLA human lung adenocarcinoma tumors. Although the plasma pharmacokinetics were similar between LY256787 and DAVLB (terminal plasma half-lives of 62
A De Bruyn et al.
Planta medica, 55(4), 364-366 (1989-08-01)
A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.
O van Tellingen et al.
Journal of chromatography, 553(1-2), 47-53 (1991-08-16)
Procedures for the determination of vinblastine (VBL), 4-O-deacetylvinblastine (DVBL) and 4-O-deacetylvinblastine-3-oic acid (DVBLA) in biological samples using high-performance liquid chromatography (HPLC) combined with selective sample clean-up are presented. VBL and DVBL were determined in plasma and urine using ion-exchange normal-phase
O van Tellingen et al.
Cancer chemotherapy and pharmacology, 32(4), 286-292 (1993-01-01)
We have developed and validated a selective analytical procedure, based on ion-exchange normal-phase liquid chromatography with fluorescence detection and liquid-liquid extraction, for the analysis of vinblastine (VBL) in biological matrices. The assay is suitable for the determination of the parent
J M Labus et al.
Cytometry, 13(3), 275-281 (1992-01-01)
Clinical investigations utilizing murine monoclonal antibodies require techniques for the detection of the human anti-mouse antibody (HAMA) response in patient serum. We report here a flow cytometric assay for the quantitation of HAMA. Commercially available beads conjugated with goat anti-mouse

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