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Merck
CN

D1954000

双氢链霉素 倍半硫酸酯

European Pharmacopoeia (EP) Reference Standard

别名:

Dihydrostreptomycin sesquisulfate

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关于此项目

线性分子式:
C21H41N7O12 · 3/2H2SO4
化学文摘社编号:
5490-27-7
分子量:
730.71
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329798719
EC Number:
226-823-7
Beilstein/REAXYS Number:
3894221
MDL number:
MFCD00070252

主要文件

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产品名称

双氢链霉素 倍半硫酸酯, European Pharmacopoeia (EP) Reference Standard

InChI

1S/2C21H41N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)CO)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)CO)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI key

CZWJCQXZZJHHRH-YZTFXSNBSA-N

grade

pharmaceutical primary standard

API family

dihydrostreptomycin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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相关类别

Application

Dihydrostreptomycin sulfate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Yves Babin et al.
Journal of AOAC International, 90(5), 1418-1426 (2007-10-25)
A liquid chromatographic/tandem mass spectrometric (LC/MS/MS) method was developed for determining dihydrostreptomycin, gentamicin C1, and neomycin in veal kidney, liver, and muscle. The extraction prior to injection on the automated cleanup/analysis system is very simple, permitting preparation of 24 veal
Aikaterini M Gremilogianni et al.
Journal of chromatography. A, 1217(43), 6646-6651 (2010-06-16)
Streptomycin (STR) and dihydrostreptomycin (DHSTR) are two of the most common aminoglycoside antibiotics used in veterinary medicine. The physicochemical properties of both substances, make their determination challenging. In the present study the development of methods based on ion-pair chromatography (IPC)
A C Whist et al.
Journal of dairy science, 90(2), 766-778 (2007-01-20)
The objective of the study was to investigate the association between early lactation Streptococcus dysgalactiae isolates and milk yield, somatic cell count (SCC), clinical mastitis, and culling in the same lactation. The 178 commercial dairy herds were randomly placed into
D A Bohm et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(2), 189-196 (2011-12-08)
A method was specifically developed for the determination and confirmation of streptomycin and dihydrostreptomycin in different types of honey. The method is simple, rapid, sensitive and was validated for streptomycin and dihydrostreptomycin in accordance with Commission Decision 2002/657/EC. After extraction
Walter Marcotti et al.
The Journal of physiology, 567(Pt 2), 505-521 (2005-07-05)
The most serious side-effect of the widely used aminoglycoside antibiotics is irreversible intracellular damage to the auditory and vestibular hair cells of the inner ear. The mechanism of entry into the hair cells has not been unequivocally resolved. Here we
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