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Merck
CN

D2255000

前列腺素F2Α氨丁三醇盐α 三羟甲基氨基甲烷盐

European Pharmacopoeia (EP) Reference Standard

别名:

(5Z,9α,11α,13E,15S)-9,11,15-三羟基前列腺-5,13-二烯酸 三羟甲基氨基甲烷盐, 前列腺素 f −Tris

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关于此项目

经验公式(希尔记法):
C20H34O5 · C4H11NO3
化学文摘社编号:
分子量:
475.62
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4087514
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grade

pharmaceutical primary standard

API family

dinoprost

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

NC(CO)(CO)CO.[H][C@]1(C\C=C/CCCC(O)=O)[C@@H](O)C[C@@H](O)[C@]1([H])\C=C\[C@@H](O)CCCCC

InChI

1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25;5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25);6-8H,1-3,5H2/b7-4-,13-12+;/t15-,16+,17+,18-,19+;/m0./s1

InChI key

IYGXEHDCSOYNKY-RZHHZEQLSA-N

Gene Information

human ... PTGFR(5737)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dinoprost trometamol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

诱导分娩的溶黄体前列腺素。肺、冠状和脑小动脉床的强效血管收缩剂。
诱导分娩的溶黄体前列腺素。肺、冠状和脑小动脉床的强效血管收缩剂。也可刺激平滑肌(如支气管)收缩,可能与哮喘有关。这种作用至少部分通过速激肽释放介导。
诱导分娩的溶黄体前列腺素。肺、冠状和脑小动脉床的强效血管收缩剂。子宫内膜 PG F 2α 之间的正反馈环黄体溶解由黄体催产素完成

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

法规信息

监管及禁止进口产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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S N Johnson et al.
Theriogenology, 55(9), 1787-1795 (2001-06-21)
Estrous response and pregnancy rates are decreased for cows given Syncro-Mate-B (SMB) during metestrus (Day 1 to 5 of an estrous cycle). Data indicate these decreases are due, in part, to retention of a functional corpus luteum (CL). Our objective
J R Pursley et al.
Theriogenology, 78(4), 823-829 (2012-05-26)
Using two PGF(2α) treatments 14 days apart as a way to enhance estrus detection rate following the 2nd treatment is a reproductive management tool that continues to be used on large dairy farms. In one study, in cows with a
K S Roy et al.
Journal of animal physiology and animal nutrition, 93(4), 486-495 (2008-05-30)
The objectives of this study were to establish the characteristics of oestrous behaviour in Ovsynch (induction of ovulation through administration of GnRH-PGF2-GnRH in a systemic manner on 0, seventh and ninth day respectively) and Ovsynch plus Norprolac (Quinagolide hydrochloride –
J E Stegner et al.
Journal of animal science, 82(4), 1016-1021 (2004-04-15)
Two progestin-based protocols for estrus synchronization in postpartum beef cows were compared following treatment administration on the basis of estrous response, interval to and synchrony of estrus, and pregnancy. Cows were assigned to one of the two treatment protocols by
M F Wright et al.
Biology of reproduction, 65(6), 1710-1717 (2001-11-22)
Recent evidence in the cow suggests that endothelin-1 (ET-1) plays a role during prostaglandin (PG) F(2alpha)-induced luteal regression. We have examined the effects of treatment with PGF(2alpha) during the early and midluteal phases on three components of the endothelin system:

全球贸易项目编号

货号GTIN
D225500004061833562031

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