SMILES string
[Cl-].[N+H]4(CCOCC4)CCC1CN(C(=O)C1(c3ccccc3)c2ccccc2)CC.O
InChI
1S/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2
InChI key
ZOMBFZRWMLIDPX-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
doxapram
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Doxapram hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Daihua Yu et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 57(9), 843-848 (2010-06-08)
The study was designed to determine the incidence of postoperative agitation following general anesthesia in 2,000 adult patients and to examine the associated risk factors. The study enrolled 2,000 adults who were scheduled for surgery under general anesthesia in a
Dennis J Murphy et al.
Journal of pharmacological and toxicological methods, 62(1), 47-53 (2010-05-04)
Assessing the effects of new chemical entities on respiratory function in animal models is an essential component of preclinical drug safety evaluation. Methods currently available for measuring ventilatory parameters in conscious dogs generally utilize a plethysmograph chamber or a face
Steeve Giguère et al.
American journal of veterinary research, 68(12), 1407-1416 (2007-12-07)
To determine and compare the effects of caffeine and doxapram on cardiorespiratory variables in foals during isoflurane-induced respiratory acidosis. 6 clinically normal foals (1 to 3 days old). At intervals of > or = 24 hours, foals received each of
J J P Goldring et al.
British journal of hospital medicine (London, England : 2005), 69(8), 444-449 (2008-09-12)
Acute-on-chronic respiratory failure is becoming an increasingly common medical emergency, mostly as a result of exacerbations of chronic obstructive pulmonary disease. It is associated with high mortality rates and so practising the best evidence-based management is vital.
Towards evidence based emergency medicine:PRIVATE best BETs from the Manchester Royal Infirmary. Bet 2: doxapram resurrected? Weak evidence of efficacy suggests a potential use in patients ineligible for non-invasive ventilation.
Emergency medicine journal : EMJ, 29(1), 78-80 (2011-12-22)
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