E1100000
麦角甾醇
European Pharmacopoeia (EP) Reference Standard
别名:
(3β)-麦角-5,7,22-三烯甘油-3-醇, 3β-羟基-5,7,22-麦角三烯, 维生素原 D2
生物来源
plant
等级
pharmaceutical primary standard
Agency
EP
API类
ergosterol
表单
solid
制造商/商品名称
EDQM
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
mp
156-158 °C (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
−20°C
SMILES字符串
[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)\C=C\[C@H](C)C(C)C
InChI
1S/C28H44O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,18-20,22,24-26,29H,11-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,26-,27-,28+/m0/s1
InChI key
DNVPQKQSNYMLRS-APGDWVJJSA-N
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危险声明
危险分类
Aquatic Chronic 4
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ergocalciferol
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 54(12), 6604-6606 (201)
Analysis of ergosterol in single kernel and ground grain by gas chromatography- mass spectrometry
Dong Y, et al.
Journal of Agricultural and Food Chemistry, 54(12), 4121-4125 (2006)
M E da Silva Ferreira et al.
Medical mycology, 43 Suppl 1, S313-S319 (2005-08-23)
The continuous use of triazoles can result in the development of drug resistance. Azole-resistant clinical isolates, spontaneous and induced mutants of Aspergillus fumigatus have been documented. The azoles block the ergosterol biosynthesis pathway by inhibiting the enzyme 14-alpha-demethylase, product of
N D Lees et al.
Lipids, 30(3), 221-226 (1995-03-01)
Research on the ergosterol biosynthetic pathway in fungi has focused on the identification of the specific sterol structure required for normal membrane structure and function and for completion of the cell cycle. The pathway and its end product are also
Mario Ruiz et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4), 1555-1567 (2013-12-24)
Lipocalins are small extracellular proteins mostly described as lipid carriers. The Drosophila lipocalin NLaz (neural Lazarillo) modulates the IIS pathway and regulates longevity, stress resistance, and behavior. Here, we test whether a native hydrophobic pocket structure is required for NLaz
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