Merck
CN

E2000000

乙硫磷酰胺

European Pharmacopoeia (EP) Reference Standard

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别名:
2-乙基-4-吡啶羧基硫代酰胺
Empirical Formula (Hill Notation):
C8H10N2S
CAS号:
分子量:
166.24
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

pharmaceutical primary standard

API family

ethionamide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CCc1cc(ccn1)C(N)=S

InChI

1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)

InChI key

AEOCXXJPGCBFJA-UHFFFAOYSA-N

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此商品
1261004Y0001686E6005
Ethionamide European Pharmacopoeia (EP) Reference Standard

E2000000

乙硫磷酰胺

Ethionamide United States Pharmacopeia (USP) Reference Standard

USP

1261004

乙硫磷酰胺

Ethionamide for system suitability European Pharmacopoeia (EP) Reference Standard

Y0001686

乙硫磷酰胺

Ethionamide

Sigma-Aldrich

E6005

乙硫磷酰胺

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

format

neat

format

neat

format

neat

format

-

API family

ethionamide

API family

ethionamide

API family

ethionamide

API family

-

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Ethionamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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[ROLE OF ETHIONAMIDE IN THE DETERMINISM OF NEUROLOGIC COMPLICATIONS OCCURRING DURING ANTITUBERCULAR TREATMENTS].
G BROUET et al.
La Revue du praticien, 14, 289-307 (1964-01-21)
Tamao Nakashita et al.
Kekkaku : [Tuberculosis], 81(12), 731-735 (2007-01-24)
Cases of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with tuberculosis have been reported, however, in most of these cases, tuberculosis disease is miliary or severe. Here we report the first case of SIADH induced by ethionamide (TH).
Kerstin A Wolff et al.
Expert review of anti-infective therapy, 10(9), 971-981 (2012-10-31)
Antifolates inhibit de novo folate biosynthesis, whereas ethionamide targets the mycolate synthetic pathway in Mycobacterium tuberculosis. These antibiotics are effective against M. tuberculosis but their use has been hampered by concerns over toxicity and low therapeutic indexes. With the increasing
Ethionamide.
Tuberculosis (Edinburgh, Scotland), 88(2), 106-108 (2008-05-20)
Nuno Vale et al.
Current drug metabolism, 14(1), 151-158 (2012-12-12)
Ethionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium. Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert

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