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文件

F0300000

叶酸

Name: 叶酸
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

N-4-[(2-氨基-4-氧代-1,4-二氢-6-喋啶)甲氨基苯甲酰基]-L-谷氨酸, PteGlu, 维生素 M

经验公式（希尔记法）:

C₁₉H₁₉N₇O₆

CAS号:

59-30-3

分子量:

441.40

Beilstein:

100781

MDL编号:

MFCD00079305

PubChem化学物质编号:

329799653

NACRES:

NA.24

生物来源

synthetic

等级

pharmaceutical primary standard

API family

folic acid

形式

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

>285 °C

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Folic acid, a water-soluble B vitamin, is available in several food products. As it is not generated in the human body, diet is one of the easiest ways to obtain it. It plays a crucial role in the biochemical synthesis and repair of DNA and is used in the management of megaloblastic anemias, neural tube defects such as anencephaly and spina bifida. Pharmaceutical drug forms of folic acid are desirable for supplementing its consumption through the diet.

应用

Folic acid may be used as an European Pharmacopoeia reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

储存分类代码

11 - Combustible Solids

WGK

WGK 1

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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索取COA

Folic acid hydrate

European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare

European pharmacopoeia, 6(5-6), 5662-5663 (2018)

Adsorptive stripping voltammetric determination of folic acid in pharmaceutical preparations

Szczepaniak W and Ren M

Electroanalysis, 6(5-6), 505-507 (1994)

Determination of folic acid in tablets by microemulsion electrokinetic chromatography

Aurora-Prado SM, et al.

Journal of Chromatography A, 1051(1-2), 291-296 (2004)

A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests

Matias R, et al.

Analytical Methods : Advancing Methods and Applications, 6(9), 3065-3071 (2014)

Flow injection chemiluminometric determination of folic acid in pharmaceutical formulations

Al-Warthan.AA

Analytical Sciences, 10(6), 919-922 (1994)

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