产品名称
Isoconazole nitrate, European Pharmacopoeia (EP) Reference Standard
SMILES string
Clc1c(c(ccc1)Cl)COC(C[n]3cncc3)c2c(cc(cc2)Cl)Cl.[N+](=O)([O-])O
InChI
1S/C18H14Cl4N2O.HNO3/c19-12-4-5-13(17(22)8-12)18(9-24-7-6-23-11-24)25-10-14-15(20)2-1-3-16(14)21;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
InChI key
NNGQLSIGRSTLLU-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
isoconazole
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Application
Isoconazole nitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Marcus Henrique de S B Xavier et al.
Dermatology online journal, 14(8), 15-15 (2008-12-09)
Tinea nigra is an asymptomatic superficial fungal infection caused by Phaeoannelomyces werneckii, generally affecting the skin of the palms and characterized by deeply pigmented macular non-scaly patches. These lesions are quite characteristic. However, they can be misdiagnosed as a malignant
Tinea cruris treated with a combined topical therapy containing isoconazole and a corticosteroid.
Jaco Jürgens
Mycoses, 51 Suppl 4, 32-33 (2008-09-12)
J Lademann et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(3), 615-620 (2012-01-31)
Bacteria and fungi are located in the stratum corneum and the hair follicles. Therefore, the development and assessment of efficient drugs requires standard in vivo investigation methods permitting a differentiation between intercellular and follicular penetration and storage of topically applied
Irina Vennewald et al.
Clinics in dermatology, 28(2), 202-211 (2010-03-30)
Aspergillus and Candida spp are the most frequently isolated fungi in patients with otomycosis. The diagnosis of otitis externa relies on the patient's history, otoscopic examination under microscopic control, and imaging studies. Direct preparation of the specimens, particularly with optical
Tinea corporis of the shin and chest successfully treated with a topical antifungal and corticosteroid cream.
Ga-Young Lee et al.
Mycoses, 51 Suppl 4, 34-36 (2008-09-12)
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