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Merck
CN

I8000010

伊维菌素

European Pharmacopoeia (EP) Reference Standard

别名:

22,23-二氢阿维菌素 B1, MK-933

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化学文摘社编号:
70288-86-7
NACRES:
NA.24
PubChem Substance ID:
329815318
UNSPSC Code:
41116107
MDL number:
MFCD00869511

主要文件

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InChI

1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

SMILES string

[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC

InChI key

AZSNMRSAGSSBNP-XPNPUAGNSA-N

grade

pharmaceutical primary standard

API family

ivermectin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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相关类别

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ivermectin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Recurrent angioedema associated with secondary eosinophilia.
M Cugno et al.
Journal of investigational allergology & clinical immunology, 23(2), 129-130 (2013-05-10)
Ivermectin for scabies and headlice: veterinary use only.
Mark N Lowenthal
The Israel Medical Association journal : IMAJ, 15(5), 262-262 (2013-07-12)
MMWR. Morbidity and mortality weekly report, 62(14), 264-266 (2013-04-12)
Strongyloides stercoralis is an intestinal nematode endemic in the tropics and subtropics. Immunocompetent hosts typically are asymptomatic, despite chronic Strongyloides infection. In contrast, immunocompromised patients are at risk for hyperinfection syndrome and disseminated disease, with a fatality rate >50%. The
Sébastien D S Pion et al.
PLoS neglected tropical diseases, 7(2), e2084-e2084 (2013-03-08)
Ivermectin has been the keystone of onchocerciasis control for the last 25 years. Sub-optimal responses to the drug have been reported in Ghanaian communities under long-term treatment. We assessed, in two Cameroonian foci, whether the microfilaricidal and/or embryostatic effects of
Topical ivermectin lotion for head lice.
Edith D Meacham
The New England journal of medicine, 368(10), 966-966 (2013-03-08)
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