产品名称
左卡尼汀, European Pharmacopoeia (EP) Reference Standard
InChI key
PHIQHXFUZVPYII-ZCFIWIBFSA-N
InChI
1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
SMILES string
C[N+](C)(C)C[C@H](O)CC([O-])=O
grade
pharmaceutical primary standard
API family
levocarnitine
manufacturer/tradename
EDQM
mp
197-212 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
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Application
左卡尼汀EP参考标准品的预期用途是欧洲药典规定的实验室测试。
Biochem/physiol Actions
肉毒碱是一种天然存在于大多数哺乳动物组织中的季铵。它在骨骼肌和心脏中参与能量代谢调控，浓度相对较高。它可将葡萄糖代谢由糖酵解转移至糖原储存，并促进长链脂肪酸向线粒体转运，使其在线粒体氧化产生能量。
General description
本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。 如需进一步信息和支持，请访问现行药典网站。
Other Notes
可能适用相应的销售限制。
Packaging
本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Andrea Lenzi et al.
Fertility and sterility, 81(6), 1578-1584 (2004-06-15)
To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. Placebo-controlled double-blind randomized trial. University tertiary referral center. Sixty infertile patients (aged 20-40 years) with the following baseline sperm selection criteria: concentration, 10 to 40
Allan M Evans et al.
Clinical pharmacokinetics, 42(11), 941-967 (2003-08-12)
L-Carnitine is a naturally occurring compound that facilitates the transport of fatty acids into mitochondria for beta-oxidation. Exogenous L-carnitine is used clinically for the treatment of carnitine deficiency disorders and a range of other conditions. In humans, the endogenous carnitine
N A Oey et al.
Placenta, 27(8), 841-846 (2005-11-23)
Carnitine plays an indispensable role in fatty acid oxidation. Previous studies revealed that fetal carnitine is derived from the mother via transplacental transfer. Recent studies demonstrated the presence and importance of an active fatty acid oxidation system in the human
Sandra Wächter et al.
Clinica chimica acta; international journal of clinical chemistry, 318(1-2), 51-61 (2002-03-07)
Long-term administration of high oral doses of L-carnitine on the skeletal muscle composition and the physical performance has not been studied in humans. Eight healthy male adults were treated with 2 x 2 g of L-carnitine per day for 3
Xiaoshan Zhou et al.
PloS one, 8(3), e58843-e58843 (2013-03-19)
Thymidine kinase 2 (TK2) deficiency in humans causes mitochondrial DNA (mtDNA) depletion syndrome. To study the molecular mechanisms underlying the disease and search for treatment options, we previously generated and described a TK2 deficient mouse strain (TK2(-/-)) that progressively loses
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