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文件

N0600000

烟酰胺

European Pharmacopoeia (EP) Reference Standard

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别名:
吡啶-3-甲酰胺, 烟碱酰胺, 烟酰胺, 维生素 B3, 维生素 PP
经验公式（希尔记法）:
C6H6N2O
CAS号:
98-92-0
分子量:
122.12
Beilstein:
383619
MDL编号:
MFCD00006395
PubChem化学物质编号:
329818447
NACRES:
NA.24

生物来源

synthetic

等级

pharmaceutical primary standard

API family

nicotinamide

形式

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

128-131 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Nicotinamide belongs to the group of water-soluble B vitamins. It is generally formed from nicotinic acid (vitamin B3). It is available in food products and is utilized for the treatment of pellagra, psoriasis, schizophrenia, and type I diabetes. It is also known for its anti-inflammatory activity.

应用

Nicotinamide can be used as an EP reference standard for the quantification of the analyte in pharmaceutical formulations and biological fluids by chromatography, UV-visible spectrophotometry and multivariate analysis.

生化/生理作用

烟酰胺是维生素B3的酰胺衍生物，是PARP抑制剂

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

相关产品

产品编号
说明
价格

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H319

危险分类

Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

302.0 °F - closed cup

闪点(°C)

150 °C - closed cup

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T1503
货号
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25G
包装规格/数量

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Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction
Chatzimichalakis PF, et al.
Journal of Separation Science, 27(14), 1181-1188 (2004)
Nicotinamide
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 14(4), 3145-3146 (2017)
Evaluation of analytical tools and multivariate methods for quantification of co-former crystals in ibuprofen-nicotinamide co-crystals
Soares FLF and Carneiro RL
Journal of Pharmaceutical and Biomedical Analysis, 89, 166-175 (2014)
Simultaneous determination and classification of riboflavin, thiamine, nicotinamide and pyridoxine in pharmaceutical formulations, by UV-visible spectrophotometry and multivariate analysis
Lopez-de-Alba LP, et al.
Journal of the Brazilian Chemical Society, 17(4), 715-722 (2006)
Mitchell E Horwitz et al.
The Journal of clinical investigation, 124(7), 3121-3128 (2014-06-10)
Delayed hematopoietic recovery is a major drawback of umbilical cord blood (UCB) transplantation. Transplantation of ex vivo-expanded UCB shortens time to hematopoietic recovery, but long-term, robust engraftment by the expanded unit has yet to be demonstrated. We tested the hypothesis
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