等级
pharmaceutical primary standard
API类
penbutolol
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(O)O.N(C[C@H](O)COc3c(cccc3)C4CCCC4)C(C)(C)C.N(C[C@H](O)COc1c(cccc1)C2CCCC2)C(C)(C)C
InChI
1S/2C18H29NO2.H2O4S/c2*1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14;1-5(2,3)4/h2*6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3;(H2,1,2,3,4)/t2*15-;/m00./s1
InChI key
FEDSNBHHWZEYTP-ZFQYHYQMSA-N
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Penbutolol sulfate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - STOT SE 3
靶器官
Central nervous system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
E A Rabiner et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 23(3), 285-293 (2000-08-16)
A novel strategy for improving the treatment of depressive illness is augmentation of antidepressants with a 5-HT1(1A) autoreceptor antagonist. However, trials using the 5-HT1(1A)/beta-blocker pindolol are proving inconsistent. We report how positron emission tomography (PET) and in vitro autoradiography can
C Aguirre et al.
Cancer chemotherapy and pharmacology, 34(1), 86-88 (1994-01-01)
The effect of in vitro treatment of serum with the alkylating agents carmustine (BCNU) and mechlorethamine on the protein binding of penbutolol, a basic agent mainly bound to alpha 1-acid glycoprotein (AAG), was investigated. The free fraction of penbutolol increased
R M Zaslavskaia et al.
Klinicheskaia meditsina, 74(9), 43-45 (1996-01-01)
Time-related effect of betapressin (penbutolol) has been studied in 24 patients with essential hypertension stage II. The drug was given in the morning, afternoon and evening in a dose 40 mg. Control group consisted of 20 patients with essential hypertension
C Aguirre et al.
Research communications in molecular pathology and pharmacology, 92(1), 53-72 (1996-04-01)
The pharmacokinetic and pharmacodynamic profiles of penbutolol were examined in healthy volunteers and in cancer patients using a pharmacokinetic/pharmacodynamic (pk/pd) model. After receiving a 40 mg single oral dose of penbutolol, the absorption rate constant, apparent volume of distribution and
C Sánchez et al.
European journal of pharmacology, 264(3), 241-247 (1994-11-03)
The inhibitory potencies of selective serotonin (5-hydroxytryptamine, 5-HT) uptake inhibitors on isolation-induced aggressive behaviour in male mice were studied. Furthermore, the role of postsynaptic 5-HT1A receptors in the mediation of aggressive behaviour was studied. The selective 5-HT uptake inhibitors, sertraline
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