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PHR1075

西咪替丁

Name: 西咪替丁
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

SKF-92334

经验公式（希尔记法）:

C₁₀H₁₆N₆S

CAS号:

51481-61-9

分子量:

252.34

EC 号:

257-232-2

MDL编号:

MFCD00133296

PubChem化学物质编号:

329823098

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 475
traceable to Ph. Eur. C2175000
traceable to USP 1134062

API类

cimetidine

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

CN\C(NC#N)=N\CCSCc1nc[nH]c1C

InChI

1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)

InChI key

AQIXAKUUQRKLND-UHFFFAOYSA-N

基因信息

human ... HRH2(3274)

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cimetidine is an H2 receptor antagonist drug. It can inhibit the photosensitive response on the skin typically induced by most of the fluoroquinolones.

应用

Cimetidine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA7170 in the slot below. This is an example certificate only and may not be the lot that you receive.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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Simultaneous determination of moxifloxacin and H2 receptor antagonist in pharmaceutical dosage formulations by RP-HPLC: application to in vitro drug interactions

Sultana N, et al.

Quimica nova, 34(4), 683-688 (2011)

Determination of cimetidine, famotidine, and ranitidine hydrochloride in the presence of their sulfoxide derivatives in pure and dosage forms by high-performance thin-layer chromatography and scanning densitometry

Kelani KM, et al.

Journal of AOAC (Association of Official Analytical Chemists) International, 85(5), 1015-1020 (2002)

Cimetidine: an immunomodulator.

A Kumar

DICP : the annals of pharmacotherapy, 24(3), 289-295 (1990-03-01)

Suppressor T lymphocytes possess histamine2 (H2) receptors and contribute significantly to the function of the immune system. Experimentally, cimetidine, an H2-receptor antagonist, has been shown to enhance a variety of immunologic functions both in vivo and in vitro because of

Clinical relevance of cimetidine drug interactions.

A F Shinn

Drug safety, 7(4), 245-267 (1992-07-01)

The excellent efficacy and tolerability profiles of H2-antagonists have established these agents as the leading class of antiulcer drugs. Attention has been focused on drug interactions with H2-antagonists as a means of product differentiation and because many patients are receiving

The fasciitis-panniculitis syndrome: clinical spectrum and response to cimetidine.

J E Naschitz et al.

Seminars in arthritis and rheumatism, 21(4), 211-220 (1992-02-01)

The term fasciitis-panniculitis syndrome (FPS) is proposed as a novel compilation encompassing several disorders, common to which is subcutaneous induration caused by cicatrizing fasciitis as well as septal and lobular panniculitis and perimysial fibrosis. Included herein are Shulman's eosinophilic fasciitis

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