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Merck
CN

PHR1079

Tobramycin

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Nebramycin Factor 6, O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine

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关于此项目

经验公式（希尔记法）:
C18H37N5O9
化学文摘社编号:
32986-56-4
分子量:
467.51
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823102
EC Number:
251-322-5
Beilstein/REAXYS Number:
1357507
MDL number:
MFCD00077885

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InChI key

NLVFBUXFDBBNBW-SNGYORCQSA-N

InChI

1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1

SMILES string

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1667508, traceable to Ph. Eur. T1500000

API family

tobramycin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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相关类别

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tobramycin is an aminoglycoside antibiotic effective in treating infections caused by Gram negative bacteria.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tobramycin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high performance liquid chromatography.

Biochem/physiol Actions

Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA5713 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

wgk

WGK 3

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361f

Hazard Classifications

Repr. 2

存储类别

11 - Combustible Solids

法规信息

涉药品监管产品
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A liquid-chromatographic method for the determination of tobramycin
Dash AK and Suryanarayanan R
Journal of Pharmaceutical and Biomedical Analysis, 9(3), 237-245 (1991)
Determination of aminoglycosides in pharmaceutical formulations-II. High-performance liquid chromatography
Fabre H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 7(12), 1711-1718 (1989)
Development of molecular imprinted nanosensor for determination of tobramycin in pharmaceuticals and foods
Yola M, et al.
Talanta, 120(2), 318-324 (2014)
A simple and rapid high-performance liquid chromatographic method for determining tobramycin in pharmaceutical formulations by direct UV detection
Ruckmani K, et al.
Pharmaceutical Methods, 2(2), 117-123 (2011)
Yifat Berkov-Zrihen et al.
Organic letters, 15(24), 6144-6147 (2013-11-15)
A short site-selective strategy for the activation and derivatization of alcohols of the clinically important aminoglycoside tobramycin is reported. The choice of amine protecting group affected the site-selective conversion of secondary alcohols of tobramycin into leaving groups. Temperature-dependent, chemoselective sequential
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