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Merck
CN

PHR1079

Supelco

Tobramycin

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Nebramycin Factor 6, O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine

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关于此项目

经验公式（希尔记法）:
C18H37N5O9
化学文摘社编号:
32986-56-4
分子量:
467.51
Beilstein:
1357507
EC 号:
251-322-5
MDL编号:
MFCD00077885
UNSPSC代码:
41116107
PubChem化学物质编号:
329823102
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

USP 1667508
traceable to Ph. Eur. T1500000

API类

tobramycin

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O

InChI

1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1

InChI key

NLVFBUXFDBBNBW-SNGYORCQSA-N

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相关类别

一般描述

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tobramycin is an aminoglycoside antibiotic effective in treating infections caused by Gram negative bacteria.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tobramycin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high performance liquid chromatography.

生化/生理作用

Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA5713 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361f

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

监管及禁止进口产品
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A simple and rapid high-performance liquid chromatographic method for determining tobramycin in pharmaceutical formulations by direct UV detection
Ruckmani K, et al.
Pharmaceutical Methods, 2(2), 117-123 (2011)
Development of molecular imprinted nanosensor for determination of tobramycin in pharmaceuticals and foods
Yola M, et al.
Talanta, 120(2), 318-324 (2014)
A liquid-chromatographic method for the determination of tobramycin
Dash AK and Suryanarayanan R
Journal of Pharmaceutical and Biomedical Analysis, 9(3), 237-245 (1991)
Determination of aminoglycosides in pharmaceutical formulations-II. High-performance liquid chromatography
Fabre H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 7(12), 1711-1718 (1989)
Stefanie Hennig et al.
Clinical pharmacokinetics, 52(4), 289-301 (2013-02-20)
While several studies have examined the pharmacokinetics of tobramycin in patients with cystic fibrosis (CF), there is no consensus on whether they differ in patients with and without CF. The objectives of this study were to identify covariates which explain
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