PHR1105
L-亮氨酸
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
(S)-2-氨基-4-甲基戊酸
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关于此项目
线性分子式:
(CH3)2CHCH2CH(NH2)CO2H
化学文摘社编号:
分子量:
131.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-522-0
Beilstein/REAXYS Number:
1721722
MDL number:
产品名称
L-亮氨酸, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
ROHFNLRQFUQHCH-YFKPBYRVSA-N
InChI
1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
SMILES string
CC(C)C[C@H](N)C(O)=O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. L0375000
traceable to USP 1357001
API family
leucine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
>300 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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Application
L-亮氨酸可用作高效液相色谱技术定量检测药物制剂中分析物的药物参考标准品。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
General description
亮氨酸是一种非生糖必需氨基酸，是蛋白质的一种结构性成分。
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
Other Notes
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
要查看该材料的分析证书示例，请在下方栏位输入 LRAA6929。这只是一个示例证书，可能不是您收到的批次。
该认证参考物质（CRM）根据 ISO 17034和 ISO/IEC 17025进行生产和认证。所有关于客户关系管理的信息都可以在分析证书上找到。
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Recent studies on the nucleotide sequence of cloned DNA complementary to mRNA for preproenkephalin from bovine adrenal medulla and human pheochromocytoma have revealed that this precursor molecule contains four copies of methionine-enkephalin (Met-Enk) and one copy each of leucine-enkephalin (Leu-Enk)
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L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into cells, stimulating mammalian target of rapamycin complex 1 signaling and protein synthesis. LAT1 and LAT3 are overexpressed at different stages of prostate cancer, and they are responsible for
William I A Haynes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4804-4814 (2013-03-15)
The identification of a hyperdirect cortico-subthalamic nucleus connection highlighted the important role of the subthalamic nucleus (STN) in regulating behavior. However, this pathway was shown primarily from motor areas. Hyperdirect pathways associated with cognitive and motivational cortical regions are particularly
T Yoshimasa et al.
The Journal of clinical investigation, 69(3), 643-650 (1982-03-01)
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these peptides in normal human sympathetic nervous system, adrenal medulla, and pheochromocytomas were determined by specific radioimmunoassays combined with
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