PHR1161
普鲁卡因 盐酸盐
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
4-氨基苯甲酸-2-二乙氨乙酯, 奴佛卡因 盐酸盐, 对氨基苯甲酸二乙氨乙酯 盐酸盐
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线性分子式:
H2NC6H4CO2CH2CH2N(C2H5)2·HCl
化学文摘社编号:
分子量:
272.77
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-077-2
Beilstein/REAXYS Number:
3917802
MDL number:
产品名称
普鲁卡因 盐酸盐, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
HCBIBCJNVBAKAB-UHFFFAOYSA-N
InChI
1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
SMILES string
Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to USP 1564006
API family
procaine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
155-156 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Application
Procaine hydrochloride can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by electrochemical, chemiluminescence, and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Procaine hydrochloride is a synthetic compound that belongs to the class of local anesthetic drugs. It has a structure similar to the natural compounds that participate in nerve impulse transmission. It shows interaction with the cellular membranes causing membrane lipids to expand, membrane-bound calcium to displace and change the structure of the proteins that are responsible for regulating the cell permeability and shape.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7177 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Improved therapeutic index of cisplatin by procaine hydrochloride
Esposito M, et al.
Journal of the National Cancer Institute, 82(8), 677-684 (1990)
Determination of procaine, benzocaine and tetracaine by sequential injection analysis with permanganate-induced chemiluminescence detection
Pasekova H and Polasek M
Talanta, 52(1), 67-75 (2000)
Colorimetric Determination of Procaine hydrochloride in Pharmaceutical Preparations using Diazotization Coupling Reactions
Al-Uzri WA and Al-Heeti MI
International Journal of PharmTech Research, 8(1), 1042-1042 (2015)
Batch and flow-injection spectrophotometric determination of procaine HCl in pharmaceutical preparations via using diazotization and coupling reaction
Al-Ward HS, et al.
Baghdad Science Journal, 9(3), 521-531 (2012)
Effect of the presence of ?-cyclodextrin on the solution behavior of procaine hydrochloride. Spectroscopic and thermodynamic studies
Merino C, et al.
Langmuir, 16(4), 1557-1565 (2000)
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