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Merck
CN

PHR1218

反式茴香脑

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

反式-1-甲氧基-4-(1-丙烯基)苯, 4-丙烯基茴香醚

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关于此项目

线性分子式:
CH3CH=CHC6H4OCH3
化学文摘社编号:
分子量:
148.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
224-052-0
Beilstein/REAXYS Number:
774229
MDL number:
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产品名称

反式茴香脑, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C10H12O/c1-3-4-9-5-7-10(11-2)8-6-9/h3-8H,1-2H3/b4-3+

InChI key

RUVINXPYWBROJD-ONEGZZNKSA-N

SMILES string

COc1ccc(\C=C\C)cc1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1035005

API family

anethole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.561 (lit.)

bp

234-237 °C (lit.)

mp

20-21 °C (lit.)

density

0.988 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

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Biochem/physiol Actions

天然存在的苯丙烯衍生物,低浓度时具有雌激素的特征,高浓度时对癌细胞系具有细胞毒性。该细胞毒性与反式茴香脑代谢为 4-羟基-1-丙烯基苯有关。

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

trans-Anethole may be used as an analytical reference standard for the determination of the analyte in raw material, food products and pharmaceutical formulations by high performance liquid chromatography and gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

trans-Anethole is an aromatic monoterpenoid compound and derivative of phenylpropene. It is predominantly used as a fragrance in cosmetics and as a flavoring agent in food and pharmaceutical industries.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Other Notes

This compound is commonly found in plants of the genus: pimpinella
To see an example of a Certificate of Analysis for this material enter LRAC3326 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation markEnvironment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

213.8 °F

flash_point_c

101 °C


分析证书(COA)

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Anethole
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 40(1)(3-4), 5576-5576 (2018)
Fast quantitative determination of volatile constituents in fennel by headspace-gas chromatography
Krizman M, et al.
Analytica Chimica Acta, 557(1-2), 267-271 (2006)
Identification by HPLC- DAD and HPLC- MS analyses and quantification of constituents of fennel teas and decoctions
Bilia AR, et al.
Journal of Agricultural and Food Chemistry, 48(10), 4734-4738 (2000)
LC determination of anethole in aniseed drinks
Jurado JM, et al.
Chromatographia, 64(3-4), 223-226 (2006)
Essential oils and their single compounds in cosmetics - A critical review
Sarkic A and Stappen I
Cosmetics, 5(1), 11-11 (2018)

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