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文件

安全信息

安全和法规

PHR1265

Carvedilol

Name: Carvedilol
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

卡维地洛

经验公式（希尔记法）:

C₂₄H₂₆N₂O₄

CAS号:

72956-09-3

分子量:

406.47

MDL编号:

MFCD00864692

PubChem化学物质编号:

329823261

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0001427
traceable to USP 1096622

API类

carvedilol

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC

InChI

1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

InChI key

OGHNVEJMJSYVRP-UHFFFAOYSA-N

基因信息

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Carvedilol is a lipophilic β₁- and β₂-adrenoreceptor antagonist that exhibits antioxidant and antiproliferative properties. It is prescribed as a medicine for the treatment of hypertension, stable angina pectoris, post myocardial infarction with left ventricular dysfunction and all degrees of symptomatic chronic heart failure.

应用

Carvedilol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.

注意

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

附注

To see an example of a Certificate of Analysis for this material enter LRAA9063 in the slot below. This is an example certificate only and may not be the lot that you receive.

1096644

1096677

1096633

1096666

1096655

1096688

Carvedilol System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

PHR2434

PHR2435

PHR2952

PHR2953

象形图

GHS09

危险声明

H411

预防措施声明

P273 - P391 - P501

危险分类

Aquatic Chronic 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

监管及禁止进口产品

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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如何查找COA批号

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如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。
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Simple and accurate RP-HPLC and TLC-Densitometric methods for determination of carvedilol in pharmaceutical formulations

Abdel-Gawad FM, et al.

International Journal of Research in Pharmacy and Chemistry, 2(3), 2231-2781 (2012)

Quantification of carvedilol in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry: application to bioequivalence study

do Carmo Borges NC, et al.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 822(1-2), 253-262 (2005)

Achiral-chiral LC/LC-FLD coupling for determination of carvedilol in plasma samples for bioequivalence purposes

Medvedovici A, et al.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 850(1-2), 327-335 (2007)

HPLC Method Development and Validation of S (-)-Carvedilol from API and Formulations

Swetha E, et al.

American Journal of Analytical Chemistry, 6(05), 437-437 (2015)

Carboxylated mesoporous carbon microparticles as new approach to improve the oral bioavailability of poorly water-soluble carvedilol.

Yanzhuo Zhang et al.

International journal of pharmaceutics, 454(1), 403-411 (2013-07-16)

The main objective of this study was to develop carboxylated ordered mesoporous carbon microparticles (c-MCMs) loaded with a poorly water-soluble drug, intended to be orally administered, able to enhance the drug loading capacity and improve the oral bioavailability. A model

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文件

安全信息

Carvedilol

Pharmaceutical Secondary Standard; Certified Reference Material

属性

等级

质量水平

Agency

API类

CofA

技术

应用

格式

储存温度

SMILES字符串

InChI

InChI key

基因信息

相关类别

说明

一般描述

应用

生化/生理作用

注意

分析说明

附注

相关产品

相关产品

安全信息

象形图

危险声明

预防措施声明

危险分类

储存分类代码

WGK

法规信息

文件

分析证书(COA)

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