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文件

PHR1282

Supelco

硫唑嘌呤

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
6-[(1-甲基-4-硝基-1H-咪唑-5-基)硫代]-1H-嘌呤
经验公式（希尔记法）:
C9H7N7O2S
CAS号:
446-86-6
分子量:
277.26
EC 号:
207-175-4
MDL编号:
MFCD00069203
PubChem化学物质编号:
329823278
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 26
traceable to Ph. Eur. A1500000
traceable to USP 1046001

API family

azathioprine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

Cn1cnc(c1Sc2ncnc3[nH]cnc23)[N+]([O-])=O

InChI

1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

InChI key

LMEKQMALGUDUQG-UHFFFAOYSA-N

Gene Information

human ... PPAT(5471)

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相关类别

一般描述

Azathioprine is a potentially useful antileukaemic drug, with immunosuppressive action, which is administered orally or by I.V route. It is widely used to treat a variety of auto-immune disorders and also has a marked effect on T-lymphocytes and suppresses cell mediated immunity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Azathioprine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using 1H NMR spectroscopy and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA0017 in the slot below. This is an example certificate only and may not be the lot that you receive.

相关产品

产品编号
说明
价格

A1500000

硫唑嘌呤, European Pharmacopoeia (EP) Reference Standard

Y0001240

硫唑嘌呤杂质A, European Pharmacopoeia (EP) Reference Standard

Y0001246

硫唑嘌呤杂质G, European Pharmacopoeia (EP) Reference Standard

1046001

硫唑嘌呤, United States Pharmacopeia (USP) Reference Standard

1045993

Azathioprine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1045938

Azathioprine Related Compound G, United States Pharmacopeia (USP) Reference Standard

BP026

硫唑嘌呤, British Pharmacopoeia (BP) Reference Standard

BP965

5-氯-1-甲基-4-硝基咪唑, British Pharmacopoeia (BP) Reference Standard

BP815

Bis-(1,7-dihydro-6H-purine)-6,6,-disulfide, British Pharmacopoeia (BP) Reference Standard

PHR2841

Azathioprine Related Compound A

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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Quantitative determination of azathioprine in tablets by 1H NMR spectroscopy
Goger GN, et al.
Journal of Pharmaceutical and Biomedical Analysis, 21(3), 685-690 (2000)
Spectrophotometric determination of azathioprine in bulk and pharmaceutical dosage forms
Bhaskar M, et al.
International Journal of ChemTech Research, 2(1), 376-378 (2010)
Systemic therapies for severe atopic dermatitis in children and adults.
Carsten Flohr et al.
The Journal of allergy and clinical immunology, 132(3), 774-774 (2013-09-03)
Joanna Kitley et al.
Journal of neurology, neurosurgery, and psychiatry, 84(8), 918-921 (2013-03-08)
Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disorder associated with considerable relapse-related disability. Immunosuppression is the mainstay of treatment but many patients do not tolerate first-line immunosuppressive agents, or experience ongoing relapses. To evaluate the effectiveness and tolerability of
Patricia M Fortin et al.
The Cochrane database of systematic reviews, 1(1), CD007057-CD007057 (2013-02-27)
Wegener's granulomatosis (WG) is a necrotizing small-vessel vasculitis that can affect any organ in the body but mainly affects the upper and lower respiratory tract, the kidneys, joints, skin and eyes. The current mainstay of remission induction therapy is systemic
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