PHR1336
尼美舒利
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
尼美舒利, N-（4-硝基-2-苯氧基苯基）甲磺酰胺
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关于此项目
经验公式（希尔记法）:
C13H12N2O5S
化学文摘社编号:
分子量:
308.31
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
257-431-4
MDL number:
产品名称
尼美舒利, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
HYWYRSMBCFDLJT-UHFFFAOYSA-N
InChI
1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
SMILES string
CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. N0845000
API family
nimesulide
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Biochem/physiol Actions
高选择性环氧化酶-2 抑制剂。
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Application
Nimesulide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor that can potentially be used as a therapeutic agent for the treatment of inflammatory conditions. It is also a non-steroidal anti-inflammatory drug (NSAID) that possesses analgesic and antipyretic characters.
Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor that can potentially be used as a therapeutic agent for the treatment of inflammatory conditions. It is also a non-steroidal anti-inflammatory drug (NSAID) that possesses analgesic and antipyretic characters.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA1070 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry
Altinoz S and Dursun OO
Journal of Pharmaceutical and Biomedical Analysis, 22(1), 175-182 (2000)
Improved high-performance liquid chromatographic assay for nimesulide
Jaworowicz Jr DJ, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 723(1-2), 293-299 (1999)
Validated HPTLC method for nimesulide and dicyclomine hydrochloride in formulation
Dhaneshwar SR, et al.
Journal of Pharmacy Research, 4(7), 2288-2290 (2011)
Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids
Nageswara Rao R, et al.
Biomedical Chromatography, 19(5), 362-368 (2005)
Development and validation of a novel RP-HPLC method for simultaneous determination of paracetamol, phenylephrine hydrochloride, caffeine, cetirizine and nimesulide in tablet formulation.
Dewani AP, et al.
Arabian Journal of Chemistry, 8(4), 591-598 (2015)
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