PHR1338
三氯生
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
三氯苯氧氯酚, 5-氯-2-（2,4-二氯苯氧基）苯酚, 氯苯酚
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关于此项目
经验公式（希尔记法）:
C12H7Cl3O2
化学文摘社编号:
分子量:
289.54
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
222-182-2
Beilstein/REAXYS Number:
2057142
MDL number:
产品名称
三氯生, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
XEFQLINVKFYRCS-UHFFFAOYSA-N
InChI
1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
SMILES string
Oc1cc(Cl)ccc1Oc2ccc(Cl)cc2Cl
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to USP 1682206
API family
triclosan
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Application
一种可能污染动物性食品的人类病原体—耶尔森氏菌的头孢菌素-伊桑-新生物素选择培养基的组成部分。
三氯生可用作药物参考标准品，用于通过各种色谱方法测定废水样品和食品中的 分析物。
这些二级标准品是经过检验的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他标定应用。
Biochem/physiol Actions
它是细菌和疟原虫II型脂肪酸合成酶(FAS-II)的烯酰ACP（酰基载体蛋白）还原酶组分的抑制剂。 它还能抑制哺乳动物脂肪酸合成酶（FASN），可能具有抗癌活性。
General description
用于质量控制的药物二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
三氯生是一种非离子型广谱抗菌和抗真菌剂，用于个人护理产品，如抗菌肥皂、牙膏、织物和塑料。
三氯生是一种非离子型广谱抗菌和抗真菌剂，用于个人护理产品，如抗菌肥皂、牙膏、织物和塑料。
Other Notes
要查看该材料的分析证书示例，请在下面的栏位中输入LRAA9502。这只是一个示例证书，可能不是您收到的批次。
该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Triclosan: applications and safety
Bhargava HN and Leonard PA
American Journal of Infection Control, 24(3), 209-218 (1996)
Determination of triclosan in foodstuffs
Sanches-Silva A, et al.
Journal of Separation Science, 28(1), 65-72 (2005)
Wai Keat Chang et al.
Annals of surgery, 255(5), 854-859 (2012-04-04)
To determine the efficacy and safety of triclosan-impregnated sutures. Surgical-site infections (SSIs) produce considerable morbidity and increase health care costs. A potential strategy to decrease the rates of SSIs may be the use of triclosan-impregnated sutures. These have been endorsed
Joseph V Rodricks et al.
Critical reviews in toxicology, 40(5), 422-484 (2010-04-10)
Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether) is an antibacterial compound that has been used in consumer products for about 40 years. The tolerability and safety of triclosan has been evaluated in human volunteers with little indication of toxicity or sensitization. Although information in
Z X Wang et al.
The British journal of surgery, 100(4), 465-473 (2013-01-23)
Surgical-site infections (SSIs) increase morbidity and mortality in surgical patients and represent an economic burden to healthcare systems. Experiments have shown that triclosan-coated sutures (TCS) are beneficial in the prevention of SSI, although the results from individual randomized controlled trials
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