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文件

PHR1340

吡拉明马来酸

Name: 吡拉明马来酸
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

吡拉明马来酸盐, Mepyramine 马来酸盐, N-(4-Methoxyphenyl)methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine 马来酸盐

经验公式（希尔记法）:

C₁₇H₂₃N₃O · C₄H₄O₄

CAS号:

59-33-6

分子量:

401.46

EC 号:

200-422-7

MDL编号:

MFCD00069333

PubChem化学物质编号:

329823325

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. M0500000
traceable to USP 1588004

API类

mepyramine, pyrilamine

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1

InChI

1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

JXYWFNAQESKDNC-BTJKTKAUSA-N

基因信息

human ... HRH1(3269)

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pyrilamine maleate is a first generation antihistamine drug, widely used to reduce all symptoms of cold and is also employed to reduce allergies both parenterally and locally.

应用

Pyrilamine maleate may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique and liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA1092 in the slot below. This is an example certificate only and may not be the lot that you receive.

警示用语：

Warning

危险声明

H302 - H315 - H319 - H335

预防措施声明

P261 - P305 + P351 + P338

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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如何查找COA批号

批号可以在产品标签上"批“ （Lot或Batch）字后面找到。

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如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。
如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。
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索取COA

Simultaneous determination of acetaminophen, pamabrom and pyrilamine maleate in pharmaceutical formulations using stability indicating HPLC assay method

Saleem A, et al.

Journal of the Mexican Chemical Society, 59(2), 93-98 (2015)

Trace analysis of the antihistamines methapyrilene hydrochloride, pyrilamine maleate and triprolidine hydrochloride monohydrate in animal feed, human urine and wastewater by high-performance liquid chromatography and gas chromatography with nitrogen?phosphorus detection.

Thompson C H and Holder L C.

Journal of Chromatography A, 283, 251-264 (1984)

Simultaneous determination of dextromethorphan hydrobromide, pyrilamine maleate and sodium benzoate in a cough cold syrup by LC

Louhaichi RM, et al.

Chromatographia, 69(5), 421-427 (2009)

Validation of a HPLC quantification of acetaminophen, phenylephrine and chlorpheniramine in pharmaceutical formulations: capsules and sachets.

Marin A, et al.

Journal of Pharmaceutical and Biomedical Analysis, 29(4), 701-714 (2002)

Histamine contributes to tissue remodeling via periostin expression.

Lingli Yang et al.

The Journal of investigative dermatology, 134(8), 2105-2113 (2014-03-01)

Histamine is thought to have a critical role in the synthesis of extracellular matrix in skin and may be involved in tissue remodeling of allergic diseases. Recent studies revealed that periostin, a matricelluar protein, contributed to tissue remodeling; however, a

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