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Merck
CN

PHR1340

吡拉明马来酸

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

吡拉明 马来酸盐, Mepyramine 马来酸盐, N-(4-Methoxyphenyl)methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine 马来酸盐

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关于此项目

经验公式（希尔记法）:
C17H23N3O · C4H4O4
化学文摘社编号:
59-33-6
分子量:
401.46
NACRES:
NA.24
PubChem Substance ID:
329823325
UNSPSC Code:
41116107
EC Number:
200-422-7
MDL number:
MFCD00069333

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产品名称

吡拉明马来酸, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

JXYWFNAQESKDNC-BTJKTKAUSA-N

InChI

1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES string

OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. M0500000
traceable to USP 1588004

API family

mepyramine, pyrilamine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... HRH1(3269)

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

Pyrilamine maleate may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique and liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pyrilamine maleate is a first generation antihistamine drug, widely used to reduce all symptoms of cold and is also employed to reduce allergies both parenterally and locally.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA1092 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Simultaneous determination of dextromethorphan hydrobromide, pyrilamine maleate and sodium benzoate in a cough cold syrup by LC
Louhaichi RM, et al.
Chromatographia, 69(5), 421-427 (2009)
Simultaneous determination of acetaminophen, pamabrom and pyrilamine maleate in pharmaceutical formulations using stability indicating HPLC assay method
Saleem A, et al.
Journal of the Mexican Chemical Society, 59(2), 93-98 (2015)
Trace analysis of the antihistamines methapyrilene hydrochloride, pyrilamine maleate and triprolidine hydrochloride monohydrate in animal feed, human urine and wastewater by high-performance liquid chromatography and gas chromatography with nitrogen?phosphorus detection.
Thompson C H and Holder L C.
Journal of Chromatography A, 283, 251-264 (1984)
Validation of a HPLC quantification of acetaminophen, phenylephrine and chlorpheniramine in pharmaceutical formulations: capsules and sachets.
Marin A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(4), 701-714 (2002)
Lingli Yang et al.
The Journal of investigative dermatology, 134(8), 2105-2113 (2014-03-01)
Histamine is thought to have a critical role in the synthesis of extracellular matrix in skin and may be involved in tissue remodeling of allergic diseases. Recent studies revealed that periostin, a matricelluar protein, contributed to tissue remodeling; however, a
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