PHR1345
齐多夫定相关化合物C
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
胸腺嘧啶, 2,4-二羟基-5-甲基嘧啶, 5-甲基尿嘧啶
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经验公式（希尔记法）:
C5H6N2O2
化学文摘社编号:
分子量:
126.11
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-616-1
Beilstein/REAXYS Number:
117880
MDL number:
产品名称
齐多夫定相关化合物C, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
RWQNBRDOKXIBIV-UHFFFAOYSA-N
InChI
1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
SMILES string
CC1=CNC(=O)NC1=O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to USP 1754532
API family
zidovudine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
~320 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Thymine (Zidovudine Related Compound C) may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
General description
Thymine (Zidovudine Related Compound C) is a process related impurity of antiretroviral drug zidovudine. Zidovudine belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors and is generally used in the prevention and treatment of HIV/AIDS.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA1097 in the slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Zidovudine
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3962-3964 (2017)
Zidovudine
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 45(1), 4630-4630 (2013)
Antiretroviral drugs
Warnke D
Journal of Clinical Pharmacology, 47(12), 1570-1579 (2007)
S I Ahmad et al.
Annual review of microbiology, 52, 591-625 (1999-01-19)
For many years it has been known that thymine auxotrophic microorganisms undergo cell death in response to thymine starvation [thymineless death (TLD)]. This effect is unusual in that deprivation of many other nutritional requirements has a biostatic, but not lethal
T R Waters et al.
Mutation research, 462(2-3), 137-147 (2000-04-18)
About 23% of mutations in hereditary human diseases and 24% of mutations in p53 in human cancers are G to A transitions at sites of cytosine methylation suggesting that these sites are either foci for DNA damage, or foci for
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