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PHR1353

雌二醇

Name: 雌二醇
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

β-雌二醇, 17β-雌二醇, 1，3，5-雌三烯-3，17β-二醇, 3,17β-二羟基-1,3,5(10)-雌三烯, 二氢卵泡素

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₄O₂

化学文摘社编号:

50-28-2

分子量:

272.38

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823337

EC Number:

200-023-8

Beilstein/REAXYS Number:

1914275

MDL number:

MFCD00003693

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1250008, traceable to Ph. Eur. E1620000

API family

estradiol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

176-180 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Gene Information

human ... ESR1(2099)

说明

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Estradiol is a steroid hormone present naturally in the human body. The availability of this hormone is quintessential in older women as it is a determinant of menopausal syndromes. It is utilized for the prevention of cardiovascular diseases.

Application

Estradiol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

绝经前卵巢分泌的主要雌激素。

绝经前卵巢分泌的主要雌激素。雌激素通过调节基因转录并因此调节蛋白质合成来指导胚胎发生和青春期女性表型的发展。它还诱导促性腺激素的产生，进而诱导排卵。暴露于雌二醇会增加乳腺癌的发生率和增殖。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC3704 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS08,GHS09

signalword

Danger

hcodes

H351,H360FD,H362,H410

pcodes

P202 - P260 - P263 - P264 - P273 - P308 + P313

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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商品

LC-MS法分析自来水中的激素

Milli-Q®超纯水系统产水不含有机污染物，包括实验室自来水中的激素，非常适合高度灵敏的LC-MS/MS分析。

Ultrapure Water Solutions for LC-MS Biomedical Testing

This study highlights the role of high-quality ultrapure water in biomedical testing for consistent and reliable LC-MS analysis.

LC-MS Analysis of Hormones in Tap Water

This study highlights the efficacy of Milli-Q^® ultrapure water to support reliable LC-MS/MS analysis of hormones in drinking water.

Prediction of internal standards in reversed-phase liquid chromatography: II. Selectivity optimization and internal standard prediction for the quantitation of estradiol and levonorgestrel in a transdermal drug delivery formulation based on the linear solvation energy relationships

Li, J and Shah DS

Journal of Chromatography A, 954(1), 159-171 (2002)

HPLC determination of estradiol, its degradation product, and preservatives in new topical formulation Estrogel HBF.

Novakova L, et al.

Analytical and Bioanalytical Chemistry, 379(5-6), 781-787 (2004)

High-efficiency liquid chromatography in pharmaceutical analysis

Bailey F. and Brittain PN

Journal of Chromatography A, 83(3), 431-437 (1973)

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全球贸易项目编号

货号	GTIN
PHR1353-1G	04061835233793