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Merck
CN

PHR1377

别嘌醇

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

别嘌醇, 1H-吡唑并 (3,4-d) 嘧啶-4-醇, 4-羟基吡唑并 (3,4-d) 嘧啶, 4-羟基吡唑并 [3,4-d] 嘧啶, HPP

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关于此项目

经验公式（希尔记法）:
C5H4N4O
化学文摘社编号:
315-30-0
分子量:
136.11
NACRES:
NA.24
PubChem Substance ID:
329823354
UNSPSC Code:
41116107
EC Number:
206-250-9
MDL number:
MFCD00599413

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InChI key

OFCNXPDARWKPPY-UHFFFAOYSA-N

InChI

1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

SMILES string

O=C1NC=Nc2[nH]ncc12

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1013002, traceable to Ph. Eur. A0350000

API family

allopurinol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... XDH(7498)

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General description

用于质量控制的药物二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
别嘌醇是一种用于治疗慢性痛风或高尿酸血症的药物。它的作用方式涉及抑制黄嘌呤氧化酶，黄嘌呤氧化酶是催化次黄嘌呤羟基化为黄嘌呤和黄嘌呤羟基化为尿酸的重要酶。

Application

别嘌醇可用作药物标准品，通过色谱技术测定药物制剂中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

Biochem/physiol Actions

黄嘌呤氧化酶和初始嘧啶生物合成的抑制剂。治疗高尿酸血症和痛风的经典药物。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

想要查看本品的检验报告示例，请在下框中输入LRAA1633。这只是一个示例证书，可能与您收到的批次不符。
该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Spectrophotometric determination of allopurinol drug in tablets: Spectroscopic characterization of the solid CT complexes.
Refat MS, et al.
Bull. Korean Chem. Soc., 31(6), 1535-1542 (2010)
Spectrophotometric determination of Allopurinol in tablet formulation.
Khayoon WShakir, et al.
Journal of Physical Science, 19(2), 23-30 (2008)
Vikram Agarwal et al.
Journal of clinical hypertension (Greenwich, Conn.), 15(6), 435-442 (2013-06-05)
Allopurinol is a potent xanthine oxidase inhibitor that is used in hyperuricemic patients to prevent gout. It has also been shown to decrease cardiovascular complications in a myriad of cardiovascular conditions. However, studies have reported conflicting evidence on its effects
Sheena N Ramasamy et al.
Drug safety, 36(10), 953-980 (2013-07-23)
Allopurinol is the primary therapy for the management of chronic gout. Utilization of allopurinol has increased in tandem with the growing prevalence of gout globally. This exposes more patients to the risk of allopurinol hypersensitivity (AH), a rare adverse reaction
Tsen-Fang Tsai et al.
American journal of clinical dermatology, 11(4), 225-232 (2010-06-01)
Off-label use is common in dermatology, and is inevitable for rare cutaneous diseases such as perforating dermatosis. Allopurinol is traditionally considered to be a drug for hyperuricemia only, but the recent demonstration of its efficacy in congestive heart failure has
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