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Merck
CN

PHR1383

腺嘌呤

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

腺嘌呤, 6-氨基嘌呤, 维生素 B4

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关于此项目

经验公式(希尔记法):
C5H5N5
化学文摘社编号:
分子量:
135.13
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-796-1
Beilstein/REAXYS Number:
5777
MDL number:
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产品名称

腺嘌呤, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

GFFGJBXGBJISGV-UHFFFAOYSA-N

InChI

1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)

SMILES string

Nc1ncnc2[nH]cnc12

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. A0230000
traceable to USP 1012101

API family

adenine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

>360 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

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Analysis Note

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

Application

腺嘌呤可用作药物标准品,用于通过高效液相色谱技术和毛细管电泳对输液溶液中的分析物进行定量。
这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

General description

用于质量控制的制药二级标准品,为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
腺嘌呤是一种嘌呤核碱基,在体内体外具有广泛的化学和生化作用。它是一种调控分子,是DNA、RNA、辅因子(NAD、FAD)和信号分子(cAMP)的组成部分。

Other Notes

该认证标准物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Development and validation of a high-performance liquid chromatography assay and a capillary electrophoresis assay for the analysis of adenosine and the degradation product adenine in infusions
Keibling P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(3), 535-539 (2004)
Henry L Y Chan et al.
Gastroenterology, 146(5), 1240-1248 (2014-01-28)
Little is known about the benefit of antiviral therapy for hepatitis B e antigen (HBeAg)-positive patients with high viral load and normal levels of alanine aminotransferase. We evaluated the effects of single and combination therapies in immune-tolerant patients with chronic
Didier Wion et al.
Nature reviews. Microbiology, 4(3), 183-192 (2006-02-21)
N(6)-methyl-adenine is found in the genomes of bacteria, archaea, protists and fungi. Most bacterial DNA adenine methyltransferases are part of restriction-modification systems. Certain groups of Proteobacteria also harbour solitary DNA adenine methyltransferases that provide signals for DNA-protein interactions. In gamma-proteobacteria
Michinori Matsuo et al.
Journal of molecular and cellular cardiology, 38(6), 907-916 (2005-05-25)
ATP-sensitive potassium (K(ATP)) channels are regulated by adenine nucleotides to convert changes in cellular metabolic levels into membrane excitability. Hence, elucidation of interaction of SUR and Kir6.x with adenine nucleotides is an important issue to understand the molecular mechanisms underlying
Kati Kaartinen et al.
Journal of the American Society of Nephrology : JASN, 25(4), 671-674 (2014-01-25)
Adenine phosphoribosyltransferase deficiency is a rare autosomal recessive disorder manifesting as urolithiasis or crystalline nephropathy. It leads to the generation of large amounts of poorly soluble 2,8-dihydroxyadenine excreted in urine, yielding kidney injury and in some patients, kidney failure. Early

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