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文件

PHR1411

亚硫酸氢钠甲萘醌

Name: 亚硫酸氢钠甲萘醌
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

甲萘醌, 2-甲基-1,4-萘醌, 维生素 K₃

经验公式（希尔记法）:

C₁₁H₈O₂

CAS号:

58-27-5

分子量:

172.18

Beilstein:

1908453

EC 号:

200-372-6

MDL编号:

MFCD00001681

PubChem化学物质编号:

329823383

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. M0300000
traceable to USP 1381006

API family

menadione

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

105-107 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CC1=CC(=O)c2ccccc2C1=O

InChI

1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3

InChI key

MJVAVZPDRWSRRC-UHFFFAOYSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Menadione is an antihemorrhagic compound and it finds application in blood clotting and bone metabolism as an essential cofactor. Additionally, at relatively higher dose, menadione exhibits antitumor activity on several human cancer cells.

应用

Menadione may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometric methods.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA2475 in the slot below. This is an example certificate only and may not be the lot that you receive.

警示用语：

Warning

危险声明

H302 - H315 - H317 - H319 - H335 - H410

预防措施声明

P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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索取COA

GC-FID and HPLC-DAD methods for the determination of menadione sodium bisulphite directly and by converting menadione sodium bisulphite to menadione in pharmaceutical preparation

Demirkaya-Miloglu F, et al.

Iranian Journal of Pharmaceutical Research : IJPR, 13(2), 353-353 (2014)

Determination by converting Menadione sodium bisulphite to Menadione in pharmaceutical preparation by two derivative spectrophotometric methods

Demirkaya-Miloglu F, et al.

European International Journal of Science and Technology, 2(2), 89-96 (2013)

Role of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways in regulating replication of Penicillium marneffei in human macrophages.

Renqiong Chen et al.

Microbes and infection, 16(5), 401-408 (2014-03-04)

Penicillium marneffei (P. marneffei) is a human pathogen which persists in macrophages and threatens the immunocompromised patients. To elucidate the mechanisms involved, we investigated the role of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38 mitogen-activated protein kinase (p38)

Signaling effects of menadione: from tyrosine phosphatase inactivation to connexin phosphorylation.

Kotb Abdelmohsen et al.

Methods in enzymology, 378, 258-272 (2004-03-25)

The Agr quorum-sensing system regulates fibronectin binding but not hemolysis in the absence of a functional electron transport chain.

Vera Pader et al.

Infection and immunity, 82(10), 4337-4347 (2014-08-06)

Staphylococcus aureus is responsible for numerous chronic and recurrent infections, which are frequently associated with the emergence of small-colony variants (SCVs) that lack a functional electron transport chain. SCVs exhibit enhanced expression of fibronectin-binding protein (FnBP) and greatly reduced hemolysin

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实验方案

HPLC Analysis of Fat Soluble Vitamins by Normal Phase Chromatography on Ascentis® Si

Separation of (±)-α-Tocopherol, analytical standard; Menadione (K3), analytical standard; (+)-γ-Tocopherol, analytical standard; Cholecalciferol (D3), analytical standard

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